1-(4-Chlorophenyl)piperazine Hydrochloride

Base Information

• Chemical Name: 1-(4-Chlorophenyl)piperazine Hydrochloride
• CAS No.: 38869-46-4
• Molecular Formula: C₁₀H₁₃ClN₂*2ClH
• Molecular Weight: 269.601
• Hs Code.: 29335990
• European Community (EC) Number: 678-801-5
• NSC Number: 71659
• DSSTox Substance ID: DTXSID60959646
• Mol file: 38869-46-4.mol

Synonyms:1-(4-Chlorophenyl)piperazine Hydrochloride;13078-12-1;1-(4-chlorophenyl)piperazine;hydrochloride;1-(4-Chlorophenyl)piperazine HCl;1-(4-Chlorophenyl)piperazine, HCl;EINECS 254-165-0;Piperazine, 1-(4-chlorophenyl)-, monohydrochloride;NSC 71659;Timtec-Bb Sbb003262;p-CPP HCl (para-Chlorophenylpiperazine Hydrochloride) 1.0 mg/ml in Methanol (as free base);para-Chlorophenylpiperazine Hydrochloride;NSC71659;1-(4-Chlorophenyl)piperazinehydrochloride;1-(4-chlorophenyl)-piperazine hydrochloride;SCHEMBL708482;DTXSID60959646;ZHGRQBSZTVJDHU-UHFFFAOYSA-N;MFCD00060187;NSC-71659;AKOS003851109;AC-25796;DS-15464;1-(4-chloro-phenyl)piperazine hydrochloride;1-(4-chlorophenyl) piperazine hydrochloride;4-(4-chlorophenyl)-piperazine hydrochloride;N-(4-chlorophenyl)-piperazine hydrochloride;C1117;CS-0444415;FT-0605702;1-(4-chloro-phenyl)-piperazine hydrochloride;F21390;1-(4-Chlorophenyl)piperazine--hydrogen chloride (1/1);p-CPP HCl (para-Chlorophenylpiperazine Hydrochloride;1-(4-Chlorophenyl)piperazine Hydrochloride)

Chemical Property of 1-(4-Chlorophenyl)piperazine Hydrochloride

Chemical Property:

• Appearance/Colour: beige to slightly brown crystalline powder
• Vapor Pressure: 0.000113mmHg at 25°C
• Melting Point: 275-278 °C (dec.)(lit.)
• Refractive Index: 1.5749 (estimate)
• Boiling Point: 394.8ºC at 760 mmHg
• Flash Point: 192.6ºC
• PSA: 15.27000
• Density: 1.1428 (rough estimate)
• LogP: 2.94540
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 232.0534038
• Heavy Atom Count: 14
• Complexity: 149

Purity/Quality:

99% ^*data from raw suppliers

1-(4-Chlorophenyl)piperazine dihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-24/25

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CN(CCN1)C2=CC=C(C=C2)Cl.Cl

Technology Process of 1-(4-Chlorophenyl)piperazine Hydrochloride

There total 1 articles about 1-(4-Chlorophenyl)piperazine Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 1-(4-chlorophenyl)piperazine dihydrochloride (13078-12-1,38869-46-4)

Guidance literature:

Reference yield: 82.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1-(4-chlorophenyl)piperazine dihydrochloride (13078-12-1,38869-46-4) + 7-Ethynylpyrazolo[1,5-a]pyridine (319432-33-2) → 3-[4-(4-chloro-phenyl)-piperazin-1-ylmethyl]-7-ethynyl-pyrazolo[1,5-a]pyridine

Guidance literature:

With N,N-dimethyl-ethanamine; acetic acid; In dichloromethane; water; at 20 ℃; for 16h;

DOI:10.1016/S0960-894X(01)00814-9

Reference yield: 79.0%

2-(4-methylpiperazin-1-yl)ethyl 4-nitrophenyl carbonate (1159928-40-1) + 1-(4-chlorophenyl)piperazine dihydrochloride (13078-12-1,38869-46-4) → 2-(4-methylpiperazin-1-yl)ethyl 4-(4-chlorophenyl)piperazine-1-carboxylate (1159928-92-3)

Guidance literature:

2-(4-methylpiperazin-1-yl)ethyl 4-nitrophenyl carbonate; 1-(4-chlorophenyl)piperazine dihydrochloride; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

With ammonia; In ethanol; dichloromethane;

Downstream raw materials:

{3-[4-(4-chloro-phenyl)-piperazin-1-ylmethyl]-pyrazolo[1,5-a]pyridin-4-yl}-methanol

Refernces