PF 1022A

Base Information

• Chemical Name: PF 1022A
• CAS No.: 133413-70-4
• Molecular Formula: C52H76N4O12
• Molecular Weight: 949.1794
• Mol file: 133413-70-4.mol

Synonyms:

Chemical Property of PF 1022A

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 89-92 °C
• Boiling Point: 1086.6°Cat760mmHg
• PKA: -1.09±0.70(Predicted)
• Flash Point: 610.9°C
• PSA: 186.44000
• Density: 1.07g/cm³
• LogP: 5.41640

Purity/Quality:

99.9% ^*data from raw suppliers

PF1022A >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PF 1022A

There total 25 articles about PF 1022A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

H-L-MeLeu-D-Lac-L-MeLeu-D-PhLac-L-MeLeu-D-Lac-L-MeLeu-D-PhLac-OH (170745-21-8) → PF1022A antipode (133413-70-4)

Guidance literature:

With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 48h;

DOI:10.1002/ejoc.201101421

Reference yield: 28.0%

pentafluorophenyl N-benzyl-N-methyl-(S)-leucyl-(R)-lactyl-N-methyl-(S)-leucyl-(R)-3-phenyllactyl-N-methyl-(S)-leucyl-(R)-lactyl-N-methyl-(S)-leucyl-(R)-3-phenyllactate → PF1022A antipode (133413-70-4)

Guidance literature:

With 2-pyrrolidinopyridine; hydrogen; palladium on activated charcoal; In 1,4-dioxane; ethanol; at 90 - 100 ℃; for 6h;

DOI:10.1016/0040-4020(95)00461-G

Reference yield:

N-methyl-L-leucyl-3-phenyl-D-lactyl-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactyl-N-methyl-L-leucyl-D-lactic acid (153052-77-8) → PF1022A antipode (133413-70-4)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 48h;

upstream raw materials:

N-methyl-L-leucyl-3-phenyl-D-lactyl-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactyl-N-methyl-L-leucyl-D-lactic acid

H-L-MeLeu-D-Lac-L-MeLeu-D-PhLac-L-MeLeu-D-Lac-L-MeLeu-D-PhLac-OH

N-t-butoxycarbonyl-N-methyl-L-leucine

benzyl N-Boc-N-methyl-L-leucyl-3-phenyl-D-lactate

Downstream raw materials:

C₅₃H₈₄N₆O₁₄

C₅₉H₈₈N₆O₁₃

C₅₅H₈₂N₈O₁₃

C₅₇H₈₄N₆O₁₃

Refernces

• 1、 Scherkenbeck, Juergen,Luettenberg, Sebastian,Ludwig, Monika,Bruecher, Karin,Kotthaus, Andreas. "Segment solid-phase total synthesis of the anthelmintic cyclooctadepsipeptides PF1022A and emodepside". experimental part. p. 1546 - 1553. Retrieved 2012/04/23.
• 2、 Scherkenbreck, Juergen,Harder, Achim,Plant, Andrew,Dyker, Hubert. "PF1022A - A novel anthelmintic cyclooctadepsipeptide. Modification and exchange of the N-methyl leucine residues". . p. 1035 - 1040. Retrieved 2007/10/03.