Malotilate

Base Information

• Chemical Name: Malotilate
• CAS No.: 59937-28-9
• Molecular Formula: C12H16O4S2
• Molecular Weight: 288.38
• European Community (EC) Number: 261-987-3
• UNII: RV59PND975
• DSSTox Substance ID: DTXSID7046463
• Nikkaji Number: J18.323G
• Wikipedia: Malotilate
• Wikidata: Q6744548
• NCI Thesaurus Code: C170147
• ChEMBL ID: CHEMBL1697754
• Mol file: 59937-28-9.mol

Synonyms:diisopropyl 1,3-dithiol-2-ylidenemalonate;malotilate;NKK 105;NKK-105

Chemical Property of Malotilate

Chemical Property:

• Vapor Pressure: 0.000296mmHg at 25°C
• Melting Point: 60.5°
• Refractive Index: 1.562
• Boiling Point: 321.53 °C at 760 mmHg
• Flash Point: 138.668 °C
• PSA: 103.20000
• Density: 1.256 g/cm³
• LogP: 3.05240
• Storage Temp.: 2-8°C
• Solubility.: soluble in Methanol,Ether,Benzene
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Exact Mass: 288.04900133
• Heavy Atom Count: 18
• Complexity: 363

Purity/Quality:

99% ^*data from raw suppliers

Malotilate >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)OC(=O)C(=C1SC=CS1)C(=O)OC(C)C
• Description: Malotilate is a hepatoprotective agent. It inhibits A23187-induced metabolism of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) to the 5-lipoxygenase (5-LO) metabolites leukotriene B4 (LTB4; ) and 5-HETE in macrophages isolated from the ascitic fluid of patients with alcoholic liver cirrhosis. Malotilate (50 mg/kg) prevents increases in plasma glutamic-pyruvic transaminase (GPT) and glutamic-oxaloacetic transaminase (GOT) activities in a rat model of carbon tetrachloride-induced liver injury. It reduces hepatic deposition of type III procollagen, type IV collagen, laminin, and fibronectin in a rat model of dimethylnitrosamine-induced hepatic fibrosis when administered at a dose of 100 mg/kg. Malotilate is a hepatoprotective agent reported to be effective in the treatment of cirrhosis, chronic hepatitis and similar liver disorders. It appears to improve hepatic function by increasing blood and bile flow and improving protein synthesis.