3,6,8-Trihydroxy-1-methylxanthone

Base Information

• Chemical Name: 3,6,8-Trihydroxy-1-methylxanthone
• CAS No.: 20716-98-7
• Molecular Formula: C14H10O5
• Molecular Weight: 258.23
• Hs Code.: 2932999099
• Mol file: 20716-98-7.mol

Synonyms:9H-Xanthen-9-one,1,3,6-trihydroxy-8- methyl-;3,6,8-Trihydroxy-1-methyl-xanthen-9-one;1,3,6-Trihydroxy-8-methyl-9H-xanthen-9-one;

Chemical Property of 3,6,8-Trihydroxy-1-methylxanthone

Chemical Property:

• Vapor Pressure: 1.7E-13mmHg at 25°C
• Melting Point: 226-228 °C
• Refractive Index: 1.731
• Boiling Point: 567.8 °C at 760 mmHg
• PKA: 6.83±0.20(Predicted)
• Flash Point: 224.7 °C
• PSA: 90.90000
• Density: 1.563 g/cm³
• LogP: 2.37140

Purity/Quality:

98%min ^*data from raw suppliers

Norlichexanthone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,6,8-Trihydroxy-1-methylxanthone

There total 10 articles about 3,6,8-Trihydroxy-1-methylxanthone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(2,4-dioxopentyl)-2,5,7-trihydroxy-2,3-dihydrobenzopyran-4-one (72327-97-0) → norlichexanthone (20716-98-7)

Guidance literature:

With potassium hydroxide; In ethanol; at 70 - 90 ℃; for 22.5h;

DOI:10.1021/jo00324a012

Reference yield:

1,6-dihydroxy-8-methyl-3-O-(4-O-methyl-β-D-glucopyranosyl)xanthone → norlichexanthone (20716-98-7)

Guidance literature:

With hydrogenchloride; water; at 90 ℃; for 15h;

DOI:10.1080/14786419.2021.1883607

Reference yield:

lichenxanthone (15222-53-4) → norlichexanthone (20716-98-7)

Guidance literature:

With boron tribromide; In dichloromethane; at 30 ℃; for 18h; Inert atmosphere; Cooling with ice;

DOI:10.1016/j.phymed.2009.07.018

upstream raw materials:

1,3,6-trimethoxy-8-methyl-9H-xanthen-9-one

1,3,6-triacetoxy-8-methyl-xanthen-9-one

2-(2,4-dioxopentyl)-2,5,7-trihydroxy-2,3-dihydrobenzopyran-4-one

8-methyl-xanthene-1,3,6-triol

Downstream raw materials:

lichenxanthone

Refernces

• 1、 Micheletti, Ana Camila,Honda, Neli Kika,Pavan, Fernando R.,Leite, Clarice Q.F.,De Fatima Cepa Matos, Maria,Perdomo, Renata Trentin,Bogo, Danielle,Alcantara, Glaucia Braz,Beatriz, Adilson. "Increment of antimycobaterial activity on lichexanthone derivatives". . p. 904 - 910. Retrieved 2014/01/06.
• 2、 Sandifer, Ronda M.,Bhattacharya, Ajit K.,Harris, Thomas M.. "Acylation of Multiple Anions of Poly-β-ketones by Hydroxy- and Alkoxybenzoates. Cyclization of the Resultant Tetraketones to Benzophenones and Xanthones". . p. 2260 - 2267. Retrieved 2007/10/02.