CID 658051

Base Information

• Chemical Name: CID 658051
• CAS No.: 29560-58-5
• Molecular Formula: C₂₂H₂₅N₃O₄S*ClH
• Molecular Weight: 463.985
• Hs Code.: 2934999090
• Mol file: 29560-58-5.mol

Synonyms:

Chemical Property of CID 658051

Chemical Property:

• Appearance/Colour: White to tan crystalline powder, soluble in water.
• Vapor Pressure: 1.54E-15mmHg at 25°C
• Melting Point: 189° (dec)
• Boiling Point: 625 °C at 760 mmHg
• Flash Point: 331.8 °C
• PSA: 96.41000
• Density: g/cm³
• LogP: 4.98450
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 6
• Exact Mass: 463.1332552
• Heavy Atom Count: 31
• Complexity: 601

Purity/Quality:

98%min ^*data from raw suppliers

MoricizineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: [H+].CCOC(=O)NC1=CC2=C(C=C1)SC3=CC=CC=C3N2C(=O)CCN4CCOCC4.[Cl-]
• Description: Moricizine hydrochloride is a phenothiazine derivative with antiarrhythmic activity developed by the Soviet Academy of Medical Sciences. It is licensed to Dupont-Sanko in a joint venture. Moricizine hydrochloride is the first drug licensed to a U.S. company by the Soviet Union and was introduced by Dupont in the U.S. in 1990 for specific use in Iife-threatening ventricular arrhythmias. This narrow indication reflects its proarrhythmic potential. The incidence of this adverse reaction, however, is lower than that of other antiarrhythmic agents.
• Uses: Cardiac depressant (anti-arrhythmic). Moricizine Hydrochloride is a Phenothiazine (P318040) derivative, which It was used as an antiarrhythmic agent. It is also shown that moracizine is effective in suppressing premature ventricular contractions, couplets, and nonsustained ventricular tachycardia.
• Therapeutic Function: Antiarrhythmic

Technology Process of CID 658051

There total 3 articles about CID 658051 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

morpholine (110-91-8,99108-56-2) + ethyl <10-(1-oxo-2-propenyl)-10H-phenothiazin-2-yl> carbamate (94989-94-3) → moricizine hydrochloride (29560-58-5)

Guidance literature:

In 1,2-dichloro-ethane; for 3.5h; Heating;

DOI:10.1007/BF00758818

Reference yield:

2-Carbethoxyamino-10-(β-chloropropionyl)phenothiazine (34749-22-9) → moricizine hydrochloride (29560-58-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / triethylamine / toluene / 2 h / Heating

2: 55 percent / 1,2-dichloro-ethane / 3.5 h / Heating

With triethylamine; In 1,2-dichloro-ethane; toluene;

DOI:10.1007/BF00758818

Reference yield:

Phenothiazine-2-carbamic acid ethyl ester (37711-29-8) → moricizine hydrochloride (29560-58-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / benzene / 3 h / Heating

2: 55 percent / 1,2-dichloro-ethane / 3.5 h / Heating

In 1,2-dichloro-ethane; benzene;

DOI:10.1007/BF00758818

upstream raw materials:

morpholine

ethyl <10-(1-oxo-2-propenyl)-10H-phenothiazin-2-yl> carbamate

Phenothiazine-2-carbamic acid ethyl ester

2-Carbethoxyamino-10-(β-chloropropionyl)phenothiazine

Downstream raw materials:

ethyl <10-H-phenothiazin-2-yl>carbamate S-oxide

ethyl <3-oxo-3H-phenothiazin-2-yl>carbamate

ethyl <10-(1-oxo-2-propenyl)-10H-phenothiazin-2-yl> carbamate

diethyl <3,10'bi-10-H-phenothiazine-2,2'-diyl>bis

Refernces