Bis (2-Carboxyethylgermanium)sesquioxide

Base Information

• Chemical Name: Bis (2-Carboxyethylgermanium)sesquioxide
• CAS No.: 12758-40-6
• Deprecated CAS: 122402-75-9,27031-31-8,31434-91-0,69992-83-2,83172-76-3,1576423-70-5,27031-31-8,31434-91-0,69992-83-2,83172-76-3
• Molecular Formula: C6H10Ge2O7
• Molecular Weight: 339.321
• Hs Code.: 2934999090
• European Community (EC) Number: 235-800-0
• NSC Number: 267004
• DSSTox Substance ID: DTXSID9065316
• Nikkaji Number: J92.671J
• Wikipedia: Propagermanium
• Wikidata: Q7250075
• NCI Thesaurus Code: C171759
• Mol file: 12758-40-6.mol

Synonyms:3,3'-(1,3-dioxo-1,3-digermoxanediyl)dipropionic acid;3-oxygermylpropionic acid polymer;Arlamol Gel;beta carboxyethylgermanium sesquioxide;bis(2-carboxyethyl)germanium sesquioxide;bis(carboxyethyl)germanium sesquioxide;carboxyethylgermanium sesquioxide;DCEFSQD;dicarboxyethenylgermanium sesquioxide;dihydrogen bis(2-carboxylatoethyl)trioxodigermanate(2-);Ge 132;Ge-132;Germanium-132;poly-trans-((2-carboxyethyl)germasesquioxane);propagermanium;proxigermanium;repagermanium;SK 818;SK-818

Chemical Property of Bis (2-Carboxyethylgermanium)sesquioxide

Chemical Property:

• Appearance/Colour: white powder
• Melting Point: 320 °C
• PKA: 3.6(at 25℃)
• PSA: 117.97000
• LogP: 0.01480
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Aqueous Base (Sparingly)
• Water Solubility.: Slightly soluble in water.
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 8
• Exact Mass: 339.8859062
• Heavy Atom Count: 15
• Complexity: 259

Purity/Quality:

99% ^*data from raw suppliers

Bis(carboxyethylgerm?anium)Sesquioxide ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C[Ge](=O)O[Ge](=O)CCC(=O)O)C(=O)O
• Recent ClinicalTrials: Controlled Trial of Angiotensin Receptor Blocker (ARB) & Chemokine Receptor Type 2 (CCR2) Antagonist for the Treatment of COVID-19
• Recent EU Clinical Trials: A pivotal Phase 3, multicenter, randomized, double-blind, placebo-controlled study of the efficacy and safety of DMX-200 in patients with focal segmental glomerulosclerosis (FSGS) who are receiving an angiotensin II receptor blocker (ARB)
• Recent NIPH Clinical Trials: Treatment with propagermanium, a CCR2 inhibitor, for diabetic nephropathy
• Description: Propagermanium, the first organogermanium compound marketed as a pharmaceutical, is indicated for the oral treatment of chronic hepatitis B. Propagermanium is reported to enhance production of interferon α/β in virus infected mice and in human peripheral blood mononuclear cells but does not inhibit the growth of various DNA or RNA viruses in vitro. Therefore, enhancement of the host immune system against virus infection was proposed to be responsible for its antiviral activity. Propagermanium also exhibits potent antitumor activity, reportedly via stimulation of T lymphocytes to produce a lyrnphokine (s), possibly interferon-y, which induces the generation and activation of cytotoxic macrophages leading to elimination of tumor cells. Propagermanium has been reported to regulate calcium metabolism and to alleviate cancerous pain and osteocope.
• Uses: A bifunctional metalloligand with metal-C (Ge-C) bonds,bis(carboxyethylgermanium) sesquioxide, has been used to make two metal-organometallic frameworks (MOMFs). bis-(carboxyethylgermanium)sesquioxide is a as a promising anti-oxidative agent. Bis(carboxyethylgermanium) sesquioxide induce INF-γ and has undergone clinical trials with promising preclinical results. Bis(2-carboxyethylgermanium(IV) sesquioxide) can be used as a precursor in the preparation of photoluminescent carbon dots, applicable as fluorescent probes in bioimaging applications. antifungal and antiseptic

Technology Process of Bis (2-Carboxyethylgermanium)sesquioxide

There total 1 articles about Bis (2-Carboxyethylgermanium)sesquioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ bis(2-carboxyethylgermanium(IV) sesquioxide) (12758-40-6,126595-07-1,83172-76-3)

Guidance literature:

aus GeO2, 1) 1N-HCl, 2) Na2HPO3, 3) NH3/ H2O, 4) 3.5N-HCl, 5) Acrylnitril, 6) Wasserstoffperoxid;