1-Butanamine, N-[(4-methylphenyl)methylene]-

Base Information

• Chemical Name: 1-Butanamine, N-[(4-methylphenyl)methylene]-
• CAS No.: 7020-93-1
• Molecular Formula: C12H17N
• Molecular Weight: 175.274
• Mol file: 7020-93-1.mol

Synonyms:

Chemical Property of 1-Butanamine, N-[(4-methylphenyl)methylene]-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Butanamine, N-[(4-methylphenyl)methylene]-

There total 19 articles about 1-Butanamine, N-[(4-methylphenyl)methylene]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-methyl-benzaldehyde (104-87-0) + N-butylamine (109-73-9,85404-21-3) → N-[(4-methylphenyl)methylene]-1-butanamine (7020-93-1)

Guidance literature:

With HC(CMeN(2,6-Et₂C₆H₃)₂₎Al(μ-S)₂AlHC(CMeN(2,6-Et₂C₆H₃))₂; In chloroform-d1; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.ica.2017.05.034

Reference yield: 86.5%

para-methylbenzonitrile (104-85-8) + N-butylamine (109-73-9,85404-21-3) → N-(4-methylbenzylidene)-4-methylbenzylamine (71022-60-1) + N-[(4-methylphenyl)methylene]-1-butanamine (7020-93-1)

Guidance literature:

With ammonium hydroxide; hydrogen; In hexane; at 80 ℃; for 12h; under 750.075 Torr; Autoclave; Green chemistry;

DOI:10.1021/acscatal.9b01597

Reference yield:

4-Methylbenzyl alcohol (589-18-4) + N-butylamine (109-73-9,85404-21-3) → N-butyl-4-methylbenzamide (5456-97-3) + 4-methyl-benzaldehyde (104-87-0) + N-[(4-methylphenyl)methylene]-1-butanamine (7020-93-1)

Guidance literature:

With 1-methyl-1H-imidazole; tetrakis(acetonitrile)copper(I) trifluoromethanesulfonate; 4,4'-Dimethoxy-2,2'-bipyridin; 9-azabicyclo<3.3.1>nonane-N-oxyl; oxygen; In tetrahydrofuran; at 20 ℃; for 10h; under 760.051 Torr; Molecular sieve;

DOI:10.1021/jacs.6b03931

upstream raw materials:

4-methyl-benzaldehyde

N-butylamine

4-Methylbenzyl alcohol

trimethyl(butyl-amino)silane

Downstream raw materials:

3-(p-Methylphenyl)-1-phenyl-2-nitropropenone

N-(4-methylbenzyl)butan-1-amine

3-Benzoyl-4-(p-methylphenyl)-5-isoxazolamine

Diethyl maleate

Refernces

• 1、 Xia, Qi,Chang, Hua-Rong,Li, Juan,Wang, Jia-Yi,Peng, Yan-Qing,Song, Gong-Hua. "Tunable Synthesis of α-Amino Boronic Esters from Available Aldehydes and Amines through Sequential One-Pot Dehydration and Copper-Catalyzed Borylacylation". . p. 2716 - 2724. Retrieved 2020/01/31.
• 2、 Zhou, Peng,Jiang, Liang,Wang, Shuguo,Hu, Xun,Wang, Hongming,Yuan, Ziliang,Zhang, Zehui. "Synthesis of Secondary Aldimines from the Hydrogenative Cross-Coupling of Nitriles and Amines over Al2O3-Supported Ni Catalysts". . p. 8413 - 8423. Retrieved 2019/09/07.