N-(4-bromophenyl)-2-methylpropanamide

Base Information

• Chemical Name: N-(4-bromophenyl)-2-methylpropanamide
• CAS No.: 7160-08-9
• Molecular Formula: C10H12BrNO
• Molecular Weight: 242.115
• Mol file: 7160-08-9.mol

Synonyms:

Chemical Property of N-(4-bromophenyl)-2-methylpropanamide

Chemical Property:

• Vapor Pressure: 1.73E-05mmHg at 25°C
• Boiling Point: 364oC at 760 mmHg
• Flash Point: 173.9oC
• PSA: 29.10000
• Density: 1.406g/cm3
• LogP: 3.11660

Purity/Quality:

95% ^*data from raw suppliers

N-(4-Bromophenyl)isobutyramide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-bromophenyl)-2-methylpropanamide

There total 4 articles about N-(4-bromophenyl)-2-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

isobutyryl chloride (79-30-1) → N-(4-bromophenyl)isobutyramide (7160-08-9)

Guidance literature:

With sodium bicarbonate; magnesium sulfate; triethylamine; In tetrahydrofuran; chloroform; 4-bromo-aniline;

Reference yield: 76.0%

N-phenylisobutyramide (4406-41-1) → N-(4-bromophenyl)isobutyramide (7160-08-9)

Guidance literature:

With bis-[(trifluoroacetoxy)iodo]benzene; sodium bromide; In ethanol; at 25 ℃; for 0.5h; regioselective reaction; Green chemistry;

DOI:10.1002/ejoc.201801058

Reference yield: 53.0%

Isobutyronitrile (78-82-0) + bis(4-bromophenyl)iodonium triflate (139139-81-4) → N-(4-bromophenyl)isobutyramide (7160-08-9)

Guidance literature:

With copper diacetate; In water; 1,2-dichloro-ethane; at 80 ℃; for 20h; Schlenk technique; Sealed tube;

upstream raw materials:

N-phenylisobutyramide

isobutyric Acid

isobutyryl chloride

Isobutyronitrile

Downstream raw materials:

N-(4-bromophenyl)isobutyrthioamide

methyl 2-(4-isobutyramidophenyl)propanoate

N-(4-methylphenyl)-2,2-dimethylacetamide

Refernces

• 1、 Cheng, Hui-cheng,Guo, Penghu,Ji, Hong-bing,Ma, Jiao-li,Zhang, Yang,Zhou, Lichao,Zhou, Xuming. "Ligand-free copper-catalyzed direct amidation of diaryliodonium salts using nitriles as amidation reagents". supporting information. . Retrieved 2021/04/19.
• 2、 Tian, Chao,Yao, Xu,Ji, Weizhe,Wang, Qian,An, Guanghui,Li, Guangming. "A para-C–H Functionalization of Aniline Derivatives via In situ Generated Bulky Hypervalent Iodinium Reagents". supporting information. p. 5972 - 5979. Retrieved 2018/11/23.