5-nitro-1-methoxyisoquinoline

Base Information

• Chemical Name: 5-nitro-1-methoxyisoquinoline
• CAS No.: 72678-03-6
• Molecular Formula: C10H8N2O3
• Molecular Weight: 204.18200
• Mol file: 72678-03-6.mol

Synonyms:1-methoxy-5-nitroisoquinoline;1-Methoxy-5-nitro-isoquinoline;1-Methoxy-5-nitroisochinolin;

Chemical Property of 5-nitro-1-methoxyisoquinoline

Chemical Property:

• Melting Point: 132 - 135 °C (methanol)
• Boiling Point: 352.8±27.0 °C(Predicted)
• PKA: 1.23±0.13(Predicted)
• PSA: 67.94000
• Density: 1.337±0.06 g/cm3(Predicted)
• LogP: 2.67480

Purity/Quality:

1-methoxy-5-nitroisoquinoline 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-nitro-1-methoxyisoquinoline

There total 7 articles about 5-nitro-1-methoxyisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-chloro-5-nitroisoquinoline (58142-97-5) + sodium methylate (124-41-4) → 1-Methoxy-5-nitroisoquinoline (72678-03-6)

Guidance literature:

In methanol; for 2h; Heating;

DOI:10.1021/jm010330+

Reference yield: 66.0%

methanol (67-56-1) + 1-chloro-5-nitroisoquinoline (58142-97-5) → 1-Methoxy-5-nitroisoquinoline (72678-03-6)

Guidance literature:

With sodium; for 1h; Heating;

Reference yield: 23.0%

1-chloro-5-nitroisoquinoline (58142-97-5) → 1-Methoxy-5-nitroisoquinoline (72678-03-6) + 1-Amino-5-nitroisoquinoline (98410-86-7)

Guidance literature:

With ammonia; In methanol; at 130 ℃; for 8h;

upstream raw materials:

methanol

1-chloro-5-nitroisoquinoline

sodium methylate

1-hydroxyisoquinoline

Downstream raw materials:

5-amino-1-methoxyisoquinoline

2-(1-methoxy-5-isoquinolineamino)-3-nitrobenzoic acid

Refernces

• 1、 -. "Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process". . . Retrieved 2008/06/13.