2-CHLORO-5-HYDROXYBENZALDEHYDE

Base Information

• Chemical Name: 2-CHLORO-5-HYDROXYBENZALDEHYDE
• CAS No.: 7310-94-3
• Molecular Formula: C7H5ClO2
• Molecular Weight: 156.569
• Hs Code.: 2913000090
• Mol file: 7310-94-3.mol

Synonyms:Benzaldehyde,2-chloro-5-hydroxy;2-Chlor-5-hydroxy-benzaldehyd;Benzaldehyde, 2-chloro-5-hydroxy-;2-chloro-5-hydroxy-benzaldehyde;

Chemical Property of 2-CHLORO-5-HYDROXYBENZALDEHYDE

Chemical Property:

• Melting Point: 110.5-111.5 °C
• Boiling Point: 272.4±20.0 °C(Predicted)
• PKA: 8.80±0.18(Predicted)
• PSA: 37.30000
• Density: 1.404±0.06 g/cm3(Predicted)
• LogP: 1.85810
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

2-Chloro-5-hydroxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Chloro-5-hydroxybenzaldehyde is used as a reagent in the synthesis of p38 inhibitors which are used for the treatment of chronic obstructive pulmonary disease. It is also used in the preparation of halogenated analogs of L-meta-tyrosine which is a biodegradable herbicide. 2-Chloro-5-hydroxybenzaldehyde may also be used as a starting material in the synthesis of chlorinated phenylephrine.

Technology Process of 2-CHLORO-5-HYDROXYBENZALDEHYDE

There total 6 articles about 2-CHLORO-5-HYDROXYBENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4-chloro-3-(hydroxymethyl)phenol (876299-47-7) → 2-chloro-5-hydroxybenzaldehyde (7310-94-3)

Guidance literature:

With manganese(IV) oxide; In acetone; for 3h; Heating / reflux;

Reference yield: 42.0%

meta-hydroxybenzaldehyde (100-83-4) → 2-chloro-5-hydroxybenzaldehyde (7310-94-3) + 3-hydroxy-4-chlorobenzaldehyde (56962-12-0) + 2-chloro-3-hydroxybenzaldehyde (56962-10-8)

Guidance literature:

meta-hydroxybenzaldehyde; With toluene-4-sulfonic acid; In water; acetonitrile; at 20 ℃; for 0.0833333h;

With N-chloro-succinimide; In water; acetonitrile; at 20 ℃; for 2h; regioselective reaction;

DOI:10.1016/j.tet.2010.06.041

Reference yield:

2-nitro-5-hydroxybenzaldehyde (42454-06-8) → 2-chloro-5-hydroxybenzaldehyde (7310-94-3)

Guidance literature:

With sodium dithionite; water; at 90 ℃; Diazotieren in salzsaurer Loesung und Behandlung mit Kupfer(I)-chlorid;

upstream raw materials:

4-Chloro-3-methylphenol

2-nitro-5-hydroxybenzaldehyde

meta-hydroxybenzaldehyde

4-chloro-3-(hydroxymethyl)phenol

Downstream raw materials:

3-(6-bromo[1,2,4]triazolo[4,3-a]pyridin-3-yl)-4-chlorophenol

4-chloro-3-piperidinomethyl-phenol

1-(3-tert-butyl-1-{3-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-1H-pyrazol-5-yl)-3-(2-{[3-(2-chloro-5-hydroxyphenyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]thio}benzyl)urea

1-{3-tert-butyl-1-[3-(2-hydroxyethoxy)phenyl]-1H-pyrazol-5-yl}-3-(2-{[3-(2-chloro-5-hydroxyphenyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]thio}benzyl)urea

Refernces

• 1、 -. "Triazolopyridinylsulfanyl derivatives as p38 MAP kinase inhibitors". Page/Page column 31. . Retrieved 2008/06/13.