Merimepodib

Base Information Edit

Chemical Name:Merimepodib
CAS No.:198821-22-6
Molecular Formula:C23H24N4O6
Molecular Weight:452.467
Hs Code.:
UNII:2ZL2BA06FU
DSSTox Substance ID:DTXSID70173639
Nikkaji Number:J1.291.375C
Wikipedia:Merimepodib
Wikidata:Q1727082
NCI Thesaurus Code:C66097
Pharos Ligand ID:9DARJUQZLK4M
Metabolomics Workbench ID:149292
ChEMBL ID:CHEMBL304087
Mol file:198821-22-6.mol

Synonyms:Merimepodib;N-3-(3-(3-methoxy-4-oxazol-5-ylphenyl)ureido)benzylcarbamic acid tetrahydrofuran-3-yl ester;VX 497;VX-497

Suppliers and Price of Merimepodib

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
Merimepodib >98%
1 g
$ 2500.00

DC Chemicals
Merimepodib >98%
250 mg
$ 1350.00

CSNpharm
Merimepodib
5mg
$ 107.00

Crysdot
Merimepodib 98+%
25mg
$ 932.00

Crysdot
Merimepodib 98+%
50mg
$ 1584.00

Crysdot
Merimepodib 98+%
10mg
$ 529.00

Crysdot
Merimepodib 98+%
5mg
$ 370.00

ChemScene
Merimepodib 98.91%
10mg
$ 200.00

ChemScene
Merimepodib 98.91%
5mg
$ 113.00

ChemScene
Merimepodib 98.91%
100mg
$ 950.00

Total 29 raw suppliers

Chemical Property of Merimepodib Edit

Chemical Property:

Vapor Pressure:4.58E-13mmHg at 25°C
Boiling Point:571.4°Cat760mmHg
PKA:11.66±0.46(Predicted)
Flash Point:299.4°C
PSA：130.93000
Density:1.36g/cm³
LogP:4.30030
Storage Temp.:Sealed in dry,Room Temperature
Solubility.:≥45.2 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
XLogP3:2.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:8
Exact Mass:452.16958450
Heavy Atom Count:33
Complexity:652

Purity/Quality:

99% ^*data from raw suppliers

Merimepodib >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=CC(=C1)NC(=O)NC2=CC=CC(=C2)CNC(=O)OC3CCOC3)C4=CN=CO4
Isomeric SMILES:COC1=C(C=CC(=C1)NC(=O)NC2=CC=CC(=C2)CNC(=O)O[C@H]3CCOC3)C4=CN=CO4
Recent ClinicalTrials:Study of Merimepodib in Combination With Remdesivir in Adult Patients With Advanced COVID-19
Description Merimepodib is an inhibitor of inosine-5''-monophosphate dehydrogenase (IMPDH; Kis = 7 and 10 nM for IMPDH type I and type II, respectively) with antiviral and immunosuppressant activities. It reduces Ebola, Lassa, chikungunya, Junin, and Zika virus titers in vitro and inhibits Zika virus replication in Huh7 cells (EC50 = 0.6 μM). Merimepodib inhibits the proliferation of PHA-stimulated T cells and SPAS-stimulated B cells (IC50s = 104 and 132 nM, respectively), effects that can be reversed by guanosine but not adenosine . In vivo, merimepodib (50 and 100 mg/kg) increases allograft survival in a murine skin transplantation model and prevents development of graft versus host disease (GVHD) in splenocyte allografted mice.
Uses Inhibition of inosine monophosphate dehydrogenase (IMPDH), which has potential antiviral, antiproliferative, antiparasitic, and immunosuppressive activity.

Technology Process of Merimepodib

There total 3 articles about Merimepodib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.4%

: carbamic acid [[3-[(phenoxycarbonyl)amino]phenyl]methyl]-(3S)-tetrahydro-3-furanyl ester

: 198821-79-3
3-methoxy-4-(1,3-oxazol-5-yl)aniline

: 198821-22-6,198821-38-4
VX-497

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In ethyl acetate; at 20 - 85 ℃; for 25h; Product distribution / selectivity; Heating / reflux;