methyl 3-piperidin-4-ylbenzoate

Base Information

• Chemical Name: methyl 3-piperidin-4-ylbenzoate
• CAS No.: 744197-23-7
• Molecular Formula: C13H17NO2
• Molecular Weight: 219.283
• Hs Code.: 2933399090
• Mol file: 744197-23-7.mol

Synonyms:

Chemical Property of methyl 3-piperidin-4-ylbenzoate

Chemical Property:

• PSA: 38.33000
• LogP: 2.26900

Purity/Quality:

98% ^*data from raw suppliers

Methyl3-(piperidin-4-yl)benzoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 3-piperidin-4-ylbenzoate

There total 2 articles about methyl 3-piperidin-4-ylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

methanol (67-56-1) + 3-(piperidin-4-yl)benzoic acid (766508-67-2) → methyl 3-(piperidin-4-yl)benzoate (744197-23-7)

Guidance literature:

With sulfuric acid; for 72h; Reflux;

Reference yield:

→ methyl 3-(piperidin-4-yl)benzoate (744197-23-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

Reference yield: 88.0%

methyl 3-(piperidin-4-yl)benzoate (744197-23-7) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 4-(3-(methoxycarbonyl)phenyl)piperidine-1-carboxylate (1016980-41-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

upstream raw materials:

methanol

3-(piperidin-4-yl)benzoic acid

Downstream raw materials:

tert-butyl 4-(3-(methoxycarbonyl)phenyl)piperidine-1-carboxylate

Refernces

• 1、 -. "TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE". Page/Page column 87. . Retrieved 2017/10/18.