5-Bromomethyl-2-fluorobenzoic acid

Base Information

• Chemical Name: 5-Bromomethyl-2-fluorobenzoic acid
• CAS No.: 773100-76-8
• Molecular Formula: C8H6BrFO2
• Molecular Weight: 233.037
• Hs Code.: 2916310090
• Mol file: 773100-76-8.mol

Synonyms:

Chemical Property of 5-Bromomethyl-2-fluorobenzoic acid

Chemical Property:

• PSA: 37.30000
• LogP: 2.41880

Purity/Quality:

99%+ ^*data from raw suppliers

5-(Bromomethyl)-2-fluorobenzoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 5-(Bromomethyl)-2-fluorobenzoic Acid can be used as aminocarboxymuconate semialdehyde decarboxylase inhibitors.

Technology Process of 5-Bromomethyl-2-fluorobenzoic acid

There total 2 articles about 5-Bromomethyl-2-fluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.7%

2-fluoro-5-methyl-benzoic acid (321-12-0) → 5-(bromomethyl)-2-fluorobenzoic acid (773100-76-8)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; at 90 ℃; for 2h; Inert atmosphere;

Reference yield:

2-fluoro-5-bromomethyl benzoic acid methyl ester (709-45-5) → 5-(bromomethyl)-2-fluorobenzoic acid (773100-76-8) + 2-fluoro-5-(hydroxymethyl)benzoic acid (481075-38-1)

Guidance literature:

With water; In methanol; Alkaline conditions;

DOI:10.1016/j.bmcl.2009.05.054

Reference yield: 51.9%

5-(bromomethyl)-2-fluorobenzoic acid (773100-76-8) → (5-(bromomethyl)-2-fluorophenyl)methanol

Guidance literature:

With diborane; In tetrahydrofuran; at 20 ℃; for 16h;

upstream raw materials:

2-fluoro-5-bromomethyl benzoic acid methyl ester

2-fluoro-5-methyl-benzoic acid

Downstream raw materials:

C₂₈H₂₇BrFNO₅S

Refernces

• 1、 -. "OXOPYRIDINE DERIVATIVES USEFUL AS AMINOCARBOXYMUCONATE SEMIALDEHYDE DECARBOXYLASE (ACMSD) INHIBITORS". Page/Page column 47. . Retrieved 2018/07/29.