Technology Process of Methanone, (2,4-dimethoxyphenyl)(4-methylphenyl)-
There total 5 articles about Methanone, (2,4-dimethoxyphenyl)(4-methylphenyl)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-methyl-N-phenylbenzamide;
With
2-fluoropyridine; trifluoromethylsulfonic anhydride;
In
dichloromethane;
at -78 - 0 ℃;
for 0.166667h;
Inert atmosphere;
1,3-Dimethoxybenzene;
In
dichloromethane;
at 0 - 20 ℃;
Inert atmosphere;
With
hydrogenchloride; water;
In
ethanol;
for 2h;
chemoselective reaction;
Inert atmosphere;
Reflux;
DOI:10.1021/acs.joc.6b01647
- Guidance literature:
-
Multi-step reaction with 2 steps
1: Lewis acid / nitrobenzene / Heating
With
Lewis acid;
In
nitrobenzene;
DOI:10.1016/0584-8539(81)80141-9
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triethylamine; dmap / dichloromethane / 0 - 23 °C / Inert atmosphere
2.1: bis(triphenylphosphine)nickel(II) chloride / diethyl ether / 0.08 h / 23 °C / Inert atmosphere; Schlenk technique
2.2: 12 h / 23 °C / Inert atmosphere; Schlenk technique
With
dmap; bis(triphenylphosphine)nickel(II) chloride; triethylamine;
In
diethyl ether; dichloromethane;
2.1: |Negishi Coupling / 2.2: |Negishi Coupling;
DOI:10.1002/chem.201602202
