Phenol, 4-(diphenylphosphinyl)-

Base Information

• Chemical Name: Phenol, 4-(diphenylphosphinyl)-
• CAS No.: 793-43-1
• Molecular Formula: C18H15O2P
• Molecular Weight: 294.29
• DSSTox Substance ID: DTXSID30385195
• Nikkaji Number: J658.791G
• Wikidata: Q82177828
• ChEMBL ID: CHEMBL1878284
• Mol file: 793-43-1.mol

Synonyms:Phenol, 4-(diphenylphosphinyl)-;4-diphenylphosphorylphenol;793-43-1;(4-hydroxyphenyl)diphenylphosphine oxide;4-(diphenylphosphoryl)phenol;4-(Diphenylphosphinyl)phenol;MLS001008586;SCHEMBL4429088;CHEMBL1878284;DTXSID30385195;QFUAZGOBONNJEI-UHFFFAOYSA-N;HMS2814H13;p-hydroxyphenyldiphenylphosphine oxide;(4-hydroxyphenyl)diphenylphosphineoxide;SMR000495807;E77617

Chemical Property of Phenol, 4-(diphenylphosphinyl)-

Chemical Property:

• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 294.08096671
• Heavy Atom Count: 21
• Complexity: 339

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)P(=O)(C2=CC=CC=C2)C3=CC=C(C=C3)O

Technology Process of Phenol, 4-(diphenylphosphinyl)-

There total 19 articles about Phenol, 4-(diphenylphosphinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(4-hydroxy-phenyl)triphenylphosphonium bromide (22883-70-1) → (4-Hydroxyphenyl)diphenylphosphine oxide (793-43-1)

Guidance literature:

(4-hydroxy-phenyl)triphenylphosphonium bromide; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 0.166667h;

With water; In tetrahydrofuran; for 3h; Reagent/catalyst;

DOI:10.1080/00397911.2020.1868006

Reference yield: 91.0%

4-(diphenylphosphoryl)benzonitrile (795-44-8) → (4-Hydroxyphenyl)diphenylphosphine oxide (793-43-1)

Guidance literature:

With boron tribromide; In dichloromethane; for 24h; Ambient temperature;

DOI:10.1021/jo00116a042

Reference yield: 80.0%

4-(diphenylphosphanyl)phenol (5068-21-3) → (4-Hydroxyphenyl)diphenylphosphine oxide (793-43-1)

Guidance literature:

With dihydrogen peroxide; In acetonitrile; at 20 ℃; for 24h; Inert atmosphere; Schlenk technique;

DOI:10.1039/c7dt02062g

upstream raw materials:

4-(diphenylphosphoryl)benzonitrile

diphenylphosphane

p-benzoquinone

4-(diphenylphosphanyl)phenol

Downstream raw materials:

Diphenyl-(4-oxiranylmethoxy-phenyl)-phosphinoxyd

p-hydroxyphenyl(diphenyl)phosphine selenide

(4-hydroxyphenyl)diphenylphosphine borane

4-(diphenylphosphanyl)phenol

Refernces

• 1、 Zhong, Chun-Hong,Huang, Wenhua. "Synthesis of tertiary phosphine oxides by alkaline hydrolysis of quaternary phosphonium zwitterions using excess t-BuOK and stoichiometric water". supporting information. p. 1537 - 1546. Retrieved 2021/01/07.
• 2、 Gou, Xue-Ya,Zhang, Bo-Sheng,Wang, Xin-Gang,Shi, Wei-Yu,Liu, Hong-Chao,An, Yang,Zhang, Zhe,Liang, Yong-Min. "Visible-light-induced ligand-free RuCl3 catalyzed C-H phosphorylation in water". supporting information. p. 4704 - 4707. Retrieved 2020/05/22.