Quinoline, 2-ethyl-3-methyl-

Base Information

• Chemical Name: Quinoline, 2-ethyl-3-methyl-
• CAS No.: 27356-52-1
• Molecular Formula: C12H13 N
• Molecular Weight: 171.242
• Hs Code.: 2933499090
• Mol file: 27356-52-1.mol

Synonyms:2-Ethyl-3-methylquinoline;NSC 138376

Chemical Property of Quinoline, 2-ethyl-3-methyl-

Chemical Property:

• Vapor Pressure: 0.0106mmHg at 25°C
• Melting Point: 57°C
• Refractive Index: 1.6093 (estimate)
• Boiling Point: 271.7°Cat760mmHg
• Flash Point: 110°C
• PSA: 12.89000
• Density: 1.032g/cm³
• LogP: 3.10560

Purity/Quality:

99%min ^*data from raw suppliers

2-ETHYL-3-METHYLQUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Quinoline, 2-ethyl-3-methyl-

There total 31 articles about Quinoline, 2-ethyl-3-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

aniline (62-53-3) + N,N-diallyl-N,N-dipropylammonium chloride → 2-ethyl-3-methylquinoline (27356-52-1) + N-propylaniline (622-80-0)

Guidance literature:

With tris(triphenylphosphine)ruthenium(II) chloride; tin(ll) chloride; In 1,4-dioxane; water; at 180 ℃; for 20h; Further Variations:; Reagents; Solvents; reaction times; Product distribution;

DOI:10.1016/S0040-4020(00)00694-3

Reference yield: 41.0%

propan-1-ol (71-23-8) + aniline (62-53-3) → 2-ethyl-3-methylquinoline (27356-52-1) + N-propylaniline (622-80-0)

Guidance literature:

With tetrachloromethane; nickel(II) acetate tetrahydrate; triethylamine; at 135 - 145 ℃; for 16h; Inert atmosphere;

DOI:10.1134/S1070428012050107

Reference yield: 28.0%

nitrobenzene (98-95-3,26969-40-4) + butan-1-ol (71-36-3) → 2-ethyl-3-methylquinoline (27356-52-1) + N-propylaniline (622-80-0) + aniline (62-53-3) + N,N-dipropylaniline (2217-07-4)

Guidance literature:

tris(triphenylphosphine)ruthenium(II) chloride; In butan-1-ol; at 180 ℃; for 4h;

DOI:10.1246/cl.1981.1067

upstream raw materials:

formaldehyd

propionaldehyde

Dimethoxymethane

aniline

Downstream raw materials:

3-methyl-2-quinolinecarboxylic acid

Refernces

• 1、 Grigor’eva,Kostyleva,Gataulin,Khazipova,Narender, Nama,Kutepov. "Aluminosilicates with Different Porous Structures in the Synthesis of 2-Ethyl-3-Methylquinoline". . p. 719 - 725. Retrieved 2019.
• 2、 Agliullin, M. R.,Bikbaeva, V. R.,Bubennov, S. V.,Filippova, N. A.,Gataulin, A. R.,Grigor’eva, N. G.,Kostyleva, S. A.,Kutepov, B. I.,Narender, Nama. "Mesoporous Aluminosilicates in the Synthesis of N-Heterocyclic Compounds". . p. 733 - 743. Retrieved 2020/02/25.