Technology Process of Benzene, 1-methyl-4-[(1-methylpropyl)sulfonyl]-, (S)-
There total 7 articles about Benzene, 1-methyl-4-[(1-methylpropyl)sulfonyl]-, (S)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium periodate;
In
methanol; water;
at 70 ℃;
for 18h;
- Guidance literature:
-
ethene; 1-[(1-bromoethyl)sulfonyl]-4-methylbenzene;
With
potassium phosphate; nickel(II) bromide 2-methoxyethyl ether complex; (4S,4'S)-2,2'-(1-phenylpropane-2,2-diyl)bis(4,5,5-triphenyl-4,5-dihydrooxazole);
In
N,N-dimethyl acetamide; 1,2-dichloro-ethane;
at 0 ℃;
for 0.166667h;
Inert atmosphere;
With
trimethoxysilane;
In
N,N-dimethyl acetamide; 1,2-dichloro-ethane;
at 0 - 18 ℃;
for 12h;
enantioselective reaction;
DOI:10.1021/jacs.9b09415
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium bromide; dihydrogen peroxide; acetic acid
2.1: potassium hydroxide
3.1: nickel(II) bromide 2-methoxyethyl ether complex; potassium phosphate; (4S,4'S)-2,2'-(1-phenylpropane-2,2-diyl)bis(4,5,5-triphenyl-4,5-dihydrooxazole) / 1,2-dichloro-ethane; N,N-dimethyl acetamide / 0.17 h / 0 °C / Inert atmosphere
3.2: 12 h / 0 - 18 °C
With
potassium phosphate; nickel(II) bromide 2-methoxyethyl ether complex; (4S,4'S)-2,2'-(1-phenylpropane-2,2-diyl)bis(4,5,5-triphenyl-4,5-dihydrooxazole); dihydrogen peroxide; acetic acid; potassium bromide; potassium hydroxide;
In
N,N-dimethyl acetamide; 1,2-dichloro-ethane;
DOI:10.1021/jacs.9b09415