2-Chlorofuran

Base Information

• Chemical Name: 2-Chlorofuran
• CAS No.: 3187-94-8
• Molecular Formula: C4H3 Cl O
• Molecular Weight: 102.52
• Hs Code.: 2932190090
• DSSTox Substance ID: DTXSID80185728
• Nikkaji Number: J27.272H
• Wikidata: Q83056808
• Mol file: 3187-94-8.mol

Synonyms:2-Chlorofuran;2-chloro-Furan;3187-94-8;Furan, 2-chloro-;2-furanyl chloride;chlorofuran;oxolyl chloride;2-furyl chloride;SCHEMBL686975;DTXSID80185728

Chemical Property of 2-Chlorofuran

Chemical Property:

• Vapor Pressure: 122mmHg at 25°C
• Refractive Index: 1.4569 (estimate)
• Boiling Point: 74°Cat760mmHg
• Flash Point: °C
• PSA: 13.14000
• Density: 1.217g/cm³
• LogP: 1.93300
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 101.9872424
• Heavy Atom Count: 6
• Complexity: 46.8

Purity/Quality:

2-Chlorofuran 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=COC(=C1)Cl

Technology Process of 2-Chlorofuran

There total 14 articles about 2-Chlorofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.6%

furan (110-00-9) + hexachloroethane (67-72-1) → 2-chlorofuran (3187-94-8)

Guidance literature:

With n-butyllithium; sodium hydrogencarbonate; In diethyl ether; water;

Reference yield: 60.0%

mercury(II)-difuryle (28752-79-6) → 2-chlorofuran (3187-94-8)

Guidance literature:

With sulfur dichloride; In carbon disulfide; for 48h; Ambient temperature;

Reference yield: 51.0%

2-furanoic acid (88-14-2) → 2-chlorofuran (3187-94-8)

Guidance literature:

With ammonium cerium (IV) nitrate; lithium chloride; at 65 ℃; for 2h;

DOI:10.1007/s11172-008-0018-7

upstream raw materials:

furan

5-chlorofuran-2-carboxylic acid

mercury(II)-difuryle

chlorine

Downstream raw materials:

N-(4-acetylphenyl)-2-diazo-3-(furan-2-yl)-N-(4-methoxybenzyl)-3-oxopropanamide

3-(furan-2-yl)-1-(2-methoxy phenyl)prop-2-yn-1-one

fur-2-ylboronic acid

2-furanoic acid

Refernces

• 1、 Nikishin,Sokova,Makhaev,Kapustina. "Solid-phase oxidative halodecarboxylation of β-arylacrylic acids with the ceric ammonium nitrate-alkali halide system". experimental part. p. 118 - 123. Retrieved 2009/04/13.
• 2、 -. "Heterocyclic sulfonamide inhibitors of beta amyloid production". . . Retrieved 2008/06/13.