Chloroformic acid 2-chloro-1-methylethyl ester

Base Information

• Chemical Name: Chloroformic acid 2-chloro-1-methylethyl ester
• CAS No.: 817-80-1
• Molecular Formula: C4H6Cl2O2
• Molecular Weight: 156.996
• Mol file: 817-80-1.mol

Synonyms:2-chloro-1-methylethyl chloroformate;1-Chlor-2-chlorcarbonyloxy-propan;Chloroformic acid 2-chloro-1-methylethyl ester;Carbonochloridic acid,2-chloro-1-methylethyl ester;Carbonochloridic acid, 2-chloro-1-methylethyl ester;Formic acid,chloro-,2-chloro-1-methylethyl ester;

Chemical Property of Chloroformic acid 2-chloro-1-methylethyl ester

Chemical Property:

• PSA: 26.30000
• LogP: 1.98910

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Chloroformic acid 2-chloro-1-methylethyl ester

There total 6 articles about Chloroformic acid 2-chloro-1-methylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

phosgene (75-44-5) + methyloxirane (75-56-9,16033-71-9) → chlorocarbonic acid-(β-chloro-isopropyl ester) (817-80-1)

Guidance literature:

With tetrabutyl-ammonium chloride; at -30 - 20 ℃; for 2h;

Reference yield: 90.0%

methyloxirane (75-56-9,16033-71-9) + trichloromethyl chloroformate (503-38-8) → chlorocarbonic acid-(β-chloro-isopropyl ester) (817-80-1)

Guidance literature:

pentabutyl propyl guanidinium chloride; silica gel; at 50 ℃; for 4h;

DOI:10.1021/jo00096a040

Reference yield:

phosgene (75-44-5) + methyloxirane (75-56-9,16033-71-9) → chlorocarbonic acid-(β-chloro-isopropyl ester) (817-80-1) + α-chloroethyl chloroformate

Guidance literature:

With tetrabutyl-ammonium chloride; at -30 - 20 ℃; Overall yield = > 99 %;

upstream raw materials:

phosgene

1-Chloro-2-propanol

methyloxirane

pyridine

Downstream raw materials:

(2-Chloro-benzoyl)-phenyl-carbamic acid 2-chloro-1-methyl-ethyl ester

(4-Chloro-benzoyl)-phenyl-carbamic acid 2-chloro-1-methyl-ethyl ester

(2-chloro-phenyl)-carbamic acid-(β-chloro-isopropyl ester)

phenyl-carbamic acid-(β-chloro-isopropyl ester)

Refernces

• 1、 -. "PROCESS FOR THE MANUFACTURING OF A POLYMER WITH URETHANE GROUPS". Page/Page column 31-33. . Retrieved 2019/03/05.
• 2、 -. "Imidazopyridine azolidinones". . . Retrieved 2008/06/13.