5-Fluoro-4-Methyl-2-nitrophenol

Base Information

• Chemical Name: 5-Fluoro-4-Methyl-2-nitrophenol
• CAS No.: 83341-28-0
• Molecular Formula: C7H6FNO3
• Molecular Weight: 171.128
• Hs Code.: 2908990000
• Mol file: 83341-28-0.mol

Synonyms:5-Fluor-4-methyl-2-nitrophenol;Phenol,5-fluoro-4-methyl-2-nitro;

Chemical Property of 5-Fluoro-4-Methyl-2-nitrophenol

Chemical Property:

• PSA: 66.05000
• LogP: 2.27110

Purity/Quality:

98% ^*data from raw suppliers

5-Fluoro-4-methyl-2-nitrophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Fluoro-4-Methyl-2-nitrophenol

There total 3 articles about 5-Fluoro-4-Methyl-2-nitrophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3-fluoro-4-methyl phenol (452-78-8) → 5-fluoro-4-methyl-2-nitrophenol (83341-28-0)

Guidance literature:

With nitric acid; In acetic acid; for 4h; Ambient temperature;

Reference yield: 73.0%

1-chloro-5-fluoro-4-methyl-2-nitrobenzene (18349-11-6) → 5-fluoro-4-methyl-2-nitrophenol (83341-28-0)

Guidance literature:

With potassium phosphate; tri-tert-butyl phosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In toluene; at 50 ℃; for 22h;

DOI:10.1016/j.tetlet.2006.11.036

Reference yield: 42.0%

→ 5-fluoro-4-methyl-2-nitrophenol (83341-28-0)

Guidance literature:

With tetrabutylammomium bromide; nitric acid; In water; 1,2-dichloro-ethane; at 20 ℃; for 3h;

upstream raw materials:

3-fluoro-4-methyl phenol

1-chloro-5-fluoro-4-methyl-2-nitrobenzene

Downstream raw materials:

2-amino-5-fluoro-4-methylphenol

1-fluoro-5-methoxy-2-methyl-4-nitro-benzene

Refernces

• 1、 -. "ANTIBIOTIC COMPOUNDS". Page/Page column 203; 204. . Retrieved 2018/03/25.
• 2、 -. "THIAZOLE SULFONAMIDE AND OXAZOLE SULFONAMIDE KINASE INHIBITORS". Page/Page column 108. . Retrieved 2010/10/03.