Carboxyfentanyl

Base Information

• Chemical Name: Carboxyfentanyl
• CAS No.: 52994-23-7
• Molecular Formula: C₂₃H₂₈N₂O₃
• Molecular Weight: 380.487
• Mol file: 52994-23-7.mol

Synonyms:

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Chemical Property of Carboxyfentanyl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carboxyfentanyl

There total 4 articles about Carboxyfentanyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

succinic acid anhydride (108-30-5) + (1-Phenethyl-piperidin-4-yl)-phenyl-amine (21409-26-7) → Carboxyfentanyl (52994-23-7)

Guidance literature:

In ethyl acetate; at 20 ℃; for 72h;

DOI:10.1021/jm061465o

Reference yield:

1-(2-phenylethyl)-4-piperidinone (39742-60-4) → Carboxyfentanyl (52994-23-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / Molecular sieve

2.1: triethylamine / dichloromethane / 1 h / Cooling with ice

2.2: 2 h / Reflux

With sodium tetrahydroborate; triethylamine; In dichloromethane;

DOI:10.1248/bpb.b18-00765

Reference yield:

aniline (62-53-3) → Carboxyfentanyl (52994-23-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / Molecular sieve

2.1: triethylamine / dichloromethane / 1 h / Cooling with ice

2.2: 2 h / Reflux

With sodium tetrahydroborate; triethylamine; In dichloromethane;

DOI:10.1248/bpb.b18-00765

upstream raw materials:

succinic acid anhydride

(1-Phenethyl-piperidin-4-yl)-phenyl-amine

succinic acid monomethylester chloride

1-(2-phenylethyl)-4-piperidinone

Refernces

• 1、 Vardanyan, Ruben S.,Cain, James P.,Haghighi, Saghar Mowlazadeh,Kumirov, Vlad K.,McIntosh, Mary I.,Sandweiss, Alexander J.,Porreca, Frank,Hruby, Victor J.. "Synthesis and Investigation of Mixed μ-Opioid and δ-Opioid Agonists as Possible Bivalent Ligands for Treatment of Pain". . p. 1228 - 1235. Retrieved 2017/03/27.
• 2、 Vardanyan, Ruben,Kumirov, Vlad K.,Nichol, Gary S.,Davis, Peg,Liktor-Busa, Erika,Rankin, David,Varga, Eva,Vanderah, Todd,Porreca, Frank,Lai, Josephine,Hruby, Victor J.. "Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands". experimental part. p. 6135 - 6142. Retrieved 2011/11/06.