4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate

Base Information

• Chemical Name: 4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate
• CAS No.: 114568-26-2
• Molecular Formula: C₂₀H₂₀N₄O₄S
• Molecular Weight: 412.469
• Mol file: 114568-26-2.mol

Synonyms:Patamostat;p-[(2-Succinimidoethyl)thio]phenyl p-guanidinobenzoate

Chemical Property of 4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate

Chemical Property:

• Vapor Pressure: 1.58E-19mmHg at 25°C
• Boiling Point: 701.5°Cat760mmHg
• Flash Point: 378.1°C
• PSA: 150.88000
• Density: 1.41g/cm³
• LogP: 3.26320

Purity/Quality:

PATAMOSTAT 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate

There total 3 articles about 4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(2-bromoethyl)-succinimide (55943-72-1) → 4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate (114568-26-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 20 percent / K₂CO₃ / ethanol / 4 h / Heating

2: pyridine / 16.5 h

With potassium carbonate; In pyridine; ethanol;

DOI:10.1248/cpb.37.2855

Reference yield:

4-(2-succinimidoethylthio)phenol (114568-48-8) + 4-guanidinobenzoyl chloride hydrochloride (7035-79-2) → 4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate (114568-26-2)

Guidance literature:

In pyridine; for 16.5h;

DOI:10.1248/cpb.37.2855

Reference yield:

→ 4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate (114568-26-2)

Guidance literature:

upstream raw materials:

4-(2-succinimidoethylthio)phenol

4-guanidinobenzoyl chloride hydrochloride

N-(2-bromoethyl)-succinimide

Downstream raw materials:

Patamostat mesylate

Refernces

• 1、 -. "Guanidinobenzoic ester derivative". . . Retrieved 2008/06/13.