Trenbolone

Base Information

• Chemical Name: Trenbolone
• CAS No.: 10161-33-8
• Deprecated CAS: 34145-12-5,39434-88-3,39434-88-3
• Molecular Formula: C18H22O2
• Molecular Weight: 270.371
• Hs Code.: 2942000000
• European Community (EC) Number: 600-229-1
• UNII: P53R4420TR
• DSSTox Substance ID: DTXSID0034192
• Nikkaji Number: J8.986I
• Wikipedia: Trenbolone
• Wikidata: Q904833
• NCI Thesaurus Code: C95072
• Metabolomics Workbench ID: 143664
• ChEMBL ID: CHEMBL3182355
• Mol file: 10161-33-8.mol

Synonyms:Estra-4,9,11-trien-3-one,17b-hydroxy- (7CI,8CI);(+)-Trenbolone;17b-Hydroxyestra-4,9,11-trien-3-one;17b-Trenbolone;9,10,11,12-Dehydro-19-nortestosterone;RU2341;Estra-4,9,11-trien-3-one,17-hydroxy-, (17b)-;Trienbolone;b-Trenbolone;Nandrolone Decanoate;

Chemical Property of Trenbolone

Chemical Property:

• Appearance/Colour: DEA Schedule III item.
• Vapor Pressure: 1.09E-11mmHg at 25°C
• Melting Point: 170 °C
• Refractive Index: 1.605
• Boiling Point: 490.8 °C at 760 mmHg
• PKA: 14.73±0.40(Predicted)
• Flash Point: 208.2 °C
• PSA: 37.30000
• Density: 1.19 g/cm³
• LogP: 3.32930
• Storage Temp.: 2-8°C
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 270.161979940
• Heavy Atom Count: 20
• Complexity: 566

Purity/Quality:

99% ^*data from raw suppliers

Trenbolone analytical standard, for drug analysis ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T,Xn,F
• Statements: 60-36-20/21/22-11
• Safety Statements: 53-22-36/37/39-45-36/37-26-16

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC12C=CC3=C4CCC(=O)C=C4CCC3C1CCC2O
• Isomeric SMILES: C[C@]12C=CC3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O
• Description: Trenbolone, also known as trienolone or trienbolone, is a kind of anabolic androgenic steroid belonging to the 19-nortestosterone group. It can be supplied to veterinary medicine of livestock in order the boost muscle growth and appetite. It can also enhance the performance of athletes. It has several physiological effects: (1) enhance protein synthesis and nitrogen retention in the muscle tissues, which boost enhanced anabolism; (2) greatly promote insulin-like growth factor-1 (IGF-1) which is a highly effective anabolic hormone; (3) Greatly increase the red blood cell count to boost blood oxygenation which leads to improved muscular endurance; (4) Inhibit glucocorticoid hormones which inhibit the growth of muscle tissue and promote fat. (5) Improve food efficiency.
• Uses: Trenbolone is a controlled substance (anabolic steroid). It is a steroid used on livestock to increase muscle growth and appetite. To increase its effective half-life, trenbolone is administered as a prodrug as an ester conjugate such as [trenbolone acetate], trenbolone enanthate, or trenbolone cyclohexylmethylcarbonate. Plasma lipases then cleave the ester group in the bloodstream leaving free trenbolone.
• Therapeutic Function: Anabolic steroid

Technology Process of Trenbolone

There total 13 articles about Trenbolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

estrone-Δ5,10,Δ9,11-diene-17-ol-3-one (5218-51-9) → trenbolone (10161-33-8)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at 20 - 25 ℃; for 2h; Large scale;

Reference yield:

(8S,11R,13S,14S,17S)-11,17-Dihydroxy-13-methyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-cyclopenta[a]phenanthren-3-one (117605-69-3) → trenbolone (10161-33-8)

Guidance literature:

With hydrogenchloride; In chloroform;

DOI:10.1007/BF00596773

Reference yield:

3-methoxy-estra-1,3,5(10)-triene-11α,17β-diol (10516-35-5) → trenbolone (10161-33-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 68 percent / Li, CH₃OH / liquid ammonia / -70 °C

2: 70 percent / CH₃CO₂H / methanol

3: pyridine bromide-perbromide, pyridine

4: HCl / CHCl₃

With pyridine; hydrogenchloride; methanol; pyridinium perbromide hydrobromide; lithium; acetic acid; In methanol; chloroform; ammonia;

DOI:10.1007/BF00596773

upstream raw materials:

(8S,11R,13S,14S,17S)-11,17-Dihydroxy-13-methyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-cyclopenta[a]phenanthren-3-one

3-methoxy-estra-1,3,5(10)-triene-11α,17β-diol

(8S,9S,11R,13S,14S,17S)-11,17-Dihydroxy-13-methyl-1,2,4,6,7,8,9,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one

(8S,9S,11R,13S,14S,17S)-3-Methoxy-13-methyl-4,6,7,8,9,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-11,17-diol

Downstream raw materials:

trenbolone acetate

Trendione

3,17-dioxoestra-4,9,11-triene

Refernces

• 1、 Peng, Yaqin,Gao, Chenghua,Zhang, Zili,Wu, Shijie,Zhao, Jing,Li, Aitao. "A Chemoenzymatic Strategy for the Synthesis of Steroid Drugs Enabled by P450 Monooxygenase-Mediated Steroidal Core Modification". . p. 2907 - 2914. Retrieved 2022/03/03.
• 2、 -. "Synthesis method of trenbolone acetate". . . Retrieved 2018/05/30.