Oxiranemethanamine, N-methyl-N-[3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]-

Base Information

• Chemical Name: Oxiranemethanamine, N-methyl-N-[3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]-
• CAS No.: 848072-60-6
• Molecular Formula: C20H22F3NO2
• Molecular Weight: 365.395
• Mol file: 848072-60-6.mol

Synonyms:

Chemical Property of Oxiranemethanamine, N-methyl-N-[3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Oxiranemethanamine, N-methyl-N-[3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]-

There total 3 articles about Oxiranemethanamine, N-methyl-N-[3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

FLUOXETINE (54910-89-3,57226-07-0,100568-02-3,100568-03-4,59333-67-4) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → methyl-oxiranylmethyl-[3-phenyl-3-[4-(trifluoromethyl)-phenoxy]-propyl]amine (848072-60-6)

Guidance literature:

With potassium carbonate; In ethanol; for 17h; cooling;

DOI:10.1016/j.bmc.2004.12.001

Reference yield:

N-benzyl-N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropyl-amine (159216-80-5) → methyl-oxiranylmethyl-[3-phenyl-3-[4-(trifluoromethyl)-phenoxy]-propyl]amine (848072-60-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: methyl chloroformate / benzene / 12 h / Heating

1.2: 65 percent / hydrazine hydrate; potassium hydroxide / propan-1-ol / 5 h / Heating

2.1: 70 percent / K₂CO₃ / ethanol / 17 h / cooling

With potassium carbonate; methyl chloroformate; In ethanol; benzene;

DOI:10.1016/j.bmc.2004.12.001

Reference yield:

C18H17F3NOS2(1-)*Na(1+) (1092361-69-7) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → methyl-oxiranylmethyl-[3-phenyl-3-[4-(trifluoromethyl)-phenoxy]-propyl]amine (848072-60-6)

Guidance literature:

With triethylamine; In methanol; for 3h; cooling;

DOI:10.1016/j.ejmech.2007.10.024

upstream raw materials:

FLUOXETINE

epichlorohydrin

N-benzyl-N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropyl-amine

C₁₈H₁₇F₃NOS₂^(1-)*Na⁽¹⁺⁾

Downstream raw materials:

C₂₅H₃₁F₃N₂O₃S₂

azepine-1-carbodithioic acid 2-hydroxy-3-{methyl-[3-phenyl-3-(4-trifluoromethyl-phenoxy)-propyl]-amino}-propyl ester

benzyl-methyl-amino-1-carbodithioic acid 2-hydroxy-3-{methyl-[3-phenyl-3-(4-trifluoromethyl-phenoxy)-propyl]-amino}-propyl ester

pyrrolidine-1-carbodithioic acid 2-hydroxy-3-{methyl-[3-phenyl-3-(4-trifluoromethyl-phenoxy)-propyl]-amino}-propyl ester

Refernces

• 1、 Bhandari, Kalpana,Srivastava, Shipra,Shanker, Girija,Nath, Chandishwar. "Substituted propanolamines and alkylamines derived from fluoxetine as potent appetite suppressants". . p. 1739 - 1747. Retrieved 2007/10/03.