1,2-Diphenyl-2-morpholinoethanone

Base Information

• Chemical Name: 1,2-Diphenyl-2-morpholinoethanone
• CAS No.: 794-06-9
• Molecular Formula: C18H19NO2
• Molecular Weight: 281.354
• NSC Number: 150064
• Nikkaji Number: J702.103H
• Mol file: 794-06-9.mol

Synonyms:794-06-9;1,2-Diphenyl-2-morpholinoethanone;27590-58-5;SCHEMBL2468109;NSC150064;NSC-150064

Chemical Property of 1,2-Diphenyl-2-morpholinoethanone

Chemical Property:

• Vapor Pressure: 3.14E-07mmHg at 25°C
• Boiling Point: 419°Cat760mmHg
• Flash Point: 207.2°C
• Density: 1.155g/cm³
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 281.141578849
• Heavy Atom Count: 21
• Complexity: 326

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C(C2=CC=CC=C2)C(=O)C3=CC=CC=C3

Technology Process of 1,2-Diphenyl-2-morpholinoethanone

There total 12 articles about 1,2-Diphenyl-2-morpholinoethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-[(4-morpholinyl)methyl]pyridine (71897-59-1) + bromobenzene (108-86-1,52753-63-6) + carbon monoxide (201230-82-2) → α-(N-morpholino)-α-phenylacetophenone (794-06-9)

Guidance literature:

With lithium hexamethyldisilazane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; nixantphos; In 1,4-dioxane; at 80 ℃; for 16h; under 760.051 Torr;

DOI:10.1039/d1sc02078a

Reference yield: 78.0%

morpholine (110-91-8,99108-56-2) + iodobenzene (591-50-4) + carbon monoxide (201230-82-2) + benzaldehyde p-toluenesulfonylhydrazone (1666-17-7) → α-(N-morpholino)-α-phenylacetophenone (794-06-9)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; 1,4-di(diphenylphosphino)-butane; In 1,4-dioxane; at 60 ℃; for 14h; Reagent/catalyst; Solvent; Temperature; chemoselective reaction; Catalytic behavior;

DOI:10.1002/asia.201801324

Reference yield: 74.0%

morpholine (110-91-8,99108-56-2) + phenyl benzyl ketone (451-40-1) → α-(N-morpholino)-α-phenylacetophenone (794-06-9)

Guidance literature:

With sodium percarbonate; ammonium iodide; In acetonitrile; at 50 ℃; for 18h;

DOI:10.1021/jo5015855

upstream raw materials:

morpholine

Desyl chloride

rac-4,4'-(1,2-Diphenylethylen)bis

(E)-N-(1,2-diphenylethenyl)morpholine

Downstream raw materials:

phenyl benzyl ketone

benzaldehyde

morpholine

4-morpholinecarboxaldehyde

Refernces

• 1、 Liu, Yiyang,Zhang, Zhen,Zhang, Songnan,Zhang, Yan,Wang, Jianbo,Zhang, Zhenhua. "Pd0-Catalyzed Four-Component Reaction of Aryl Halide, CO, N-Tosylhydrazone, and Amine". supporting information. p. 3658 - 3663. Retrieved 2018/10/31.
• 2、 Jiang, Qing,Xu, Bin,Zhao, An,Jia, Jing,Liu, Tian,Guo, Cancheng. "Transition-metal-free oxidative α-C-H amination of ketones via a radical mechanism: Mild synthesis of α-amino ketones". . p. 8750 - 8756. Retrieved 2015/01/08.