Althiazide

Base Information

• Chemical Name: Althiazide
• CAS No.: 5588-16-9
• Molecular Formula: C₁₁H₁₄ClN₃O₄S₃
• Molecular Weight: 383.901
• European Community (EC) Number: 226-994-8
• NSC Number: 757786
• UNII: GI8CB72B0D,JI3ZO158IN,D9KLS88BLV
• DSSTox Substance ID: DTXSID3045857
• Nikkaji Number: J8.012H
• Wikipedia: Altizide
• Wikidata: Q100785603
• NCI Thesaurus Code: C80838
• ChEMBL ID: CHEMBL599870
• Mol file: 5588-16-9.mol

Synonyms:3-((allylthio)methyl)-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide;althiazide;altizide;altozide

Chemical Property of Althiazide

Chemical Property:

• Vapor Pressure: 1.4E-15mmHg at 25°C
• Melting Point: 206-207°
• Refractive Index: 1.613
• Boiling Point: 625.8 °C at 760 mmHg
• PKA: 8.33±0.40(Predicted)
• Flash Point: 332.3 °C
• PSA: 160.42000
• Density: 1.502 g/cm³
• LogP: 4.26520
• Storage Temp.: 2-8°C
• Solubility.: Practically insoluble in water, soluble in methanol, practically insoluble in dichloromethane.
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 5
• Exact Mass: 382.9834972
• Heavy Atom Count: 22
• Complexity: 614

Purity/Quality:

99%, ^*data from raw suppliers

Althiazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C=CCSCC1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl
• Therapeutic Function: Diuretic, Antihypertensive

Technology Process of Althiazide

There total 1 articles about Althiazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ althiazide (5588-16-9,133562-97-7,133585-76-9)

Guidance literature:

Reference yield:

althiazide (5588-16-9,133562-97-7,133585-76-9) → althiazide + althiazide

Guidance literature:

With N-[(R)-1-(1-naphthyl)ethyl]carbamoyl-derivatized cyclofructan-6 column; In ethanol; n-heptane; trifluoroacetic acid; at 20 ℃; Resolution of racemate;

DOI:10.1021/ac902257a