4-Methoxypiperidine

Base Information

• Chemical Name: 4-Methoxypiperidine
• CAS No.: 4045-24-3
• Molecular Formula: C6H13NO
• Molecular Weight: 115.175
• Hs Code.: 29339900
• European Community (EC) Number: 223-742-9
• UNII: TQT8YK55HT
• DSSTox Substance ID: DTXSID80193464
• Nikkaji Number: J217.858C
• Wikidata: Q72518063
• Mol file: 4045-24-3.mol

Synonyms:4-Methoxypiperidine;4045-24-3;4-Methoxy-piperidine;Piperidine, 4-methoxy-;MFCD04115010;TQT8YK55HT;EINECS 223-742-9;4-methoxypiperdine;4-methoxy piperidine;F2158-0858;4-methoxyl piperidine;UNII-TQT8YK55HT;SCHEMBL8268;4-Methoxypiperidine, AldrichCPR;SCHEMBL10297343;DTXSID80193464;BBL025762;STK500850;AKOS000119215;PB34075;PS-5545;SY003146;A6767;AM20100080;BB 0254055;CS-0040128;FT-0601766;EN300-24135;AB00988442-01;W-111718;Z169511496

Chemical Property of 4-Methoxypiperidine

Chemical Property:

• Appearance/Colour: Clear colorless liquid
• Vapor Pressure: 3.93mmHg at 25°C
• Boiling Point: 149.9 °C at 760 mmHg
• PKA: 9.83±0.10(Predicted)
• Flash Point: 49.7 °C
• PSA: 21.26000
• Density: 0.93 g/cm³
• LogP: 0.71360
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 115.099714038
• Heavy Atom Count: 8
• Complexity: 59.5

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Methoxypiperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22-20/21/22
• Safety Statements: 23-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1CCNCC1

Technology Process of 4-Methoxypiperidine

There total 10 articles about 4-Methoxypiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzyl 4-methoxypiperidine-1-carboxylate (553672-12-1) → 4-methoxypiperidine (4045-24-3)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 3h;

Reference yield: 91.0%

4-methoxypyridine (620-08-6,1232006-56-2) → 4-methoxypiperidine (4045-24-3)

Guidance literature:

With platinum on carbon; hydrogen; In acetic acid; at 80 ℃; under 22502.3 Torr; Continuous flow;

DOI:10.1002/ejoc.200801131

Reference yield: 33.0%

4-methoxy-piperidine-1-carbaldehyde (141047-49-6) → 4-methoxypiperidine (4045-24-3)

Guidance literature:

With potassium hydroxide; water; at 20 ℃; for 24h;

upstream raw materials:

4-methoxypyridine

sodium methylate

4-methoxy-piperidine-1-carbaldehyde

4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl-amine

Downstream raw materials:

10-<3-(4-Methoxy-piperidino)-propyl>-phenoxazin

4-methoxypiperidine amide of L-phenyllactic acid

C₁₃H₁₉N₃O₃

Refernces

• 1、 -. "NEW BRADYKININ B1 ANTAGONISTS". Page/Page column 202. . Retrieved 2010/04/03.
• 2、 -. "NOVEL 4-AMINO-THIENO[3,2-C]PYRIDINE-7-CARBOXYLIC ACID AMIDES". Page/Page column 45. . Retrieved 2010/11/26.