2H-Pyran, tetrahydro-2-[(2,3,5,6-tetrafluorophenyl)methoxy]-

Base Information

• Chemical Name: 2H-Pyran, tetrahydro-2-[(2,3,5,6-tetrafluorophenyl)methoxy]-
• CAS No.: 84937-77-9
• Molecular Formula: C12H12F4O2
• Molecular Weight: 264.22
• Mol file: 84937-77-9.mol

Synonyms:

Chemical Property of 2H-Pyran, tetrahydro-2-[(2,3,5,6-tetrafluorophenyl)methoxy]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2H-Pyran, tetrahydro-2-[(2,3,5,6-tetrafluorophenyl)methoxy]-

There total 2 articles about 2H-Pyran, tetrahydro-2-[(2,3,5,6-tetrafluorophenyl)methoxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) + 2,6-dichloro-3,5-difluorobenzyl alcohol → tetrahydro-2-[(2,3,5,6-tetrafluorophenyl)methoxy]-2H-pyran (84937-77-9)

Guidance literature:

With p-toluenesulfonic acid monohydrate; In dichloromethane; at 20 ℃; for 22h;

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) + (2,3,5,6-tetrafluorophenyl)methanol (4084-38-2) → tetrahydro-2-[(2,3,5,6-tetrafluorophenyl)methoxy]-2H-pyran (84937-77-9)

Guidance literature:

With toluene-4-sulfonic acid; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1016/j.jfluchem.2009.07.008

Reference yield:

tetrahydro-2-[(2,3,5,6-tetrafluorophenyl)methoxy]-2H-pyran (84937-77-9) + methyl iodide (74-88-4) → tetrahydro-2-[(4-methyl-2,3,5,6-tetrafluorophenyl)methoxy]-2H-pyran (289891-56-1)

Guidance literature:

tetrahydro-2-[(2,3,5,6-tetrafluorophenyl)methoxy]-2H-pyran; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 2.5h;

methyl iodide; In tetrahydrofuran; for 1h;

DOI:10.1016/j.jfluchem.2009.07.008

upstream raw materials:

3,4-dihydro-2H-pyran

(2,3,5,6-tetrafluorophenyl)methanol

Downstream raw materials:

tetrahydro-2-[(4-methyl-2,3,5,6-tetrafluorophenyl)methoxy]-2H-pyran

Refernces

• 1、 Zhang, Deyan,Chen, Zizhan,Cai, Huihua,Zou, Xinzhuo. "A new synthetic route to polyfluorobenzyl alcohol". experimental part. p. 938 - 941. Retrieved 2010/01/15.