Piperazine, 1-[(4-bromophenyl)sulfonyl]-4-(2-methoxyethyl)-

Base Information

• Chemical Name: Piperazine, 1-[(4-bromophenyl)sulfonyl]-4-(2-methoxyethyl)-
• CAS No.: 849532-11-2
• Molecular Formula: C13H19BrN2O3S
• Molecular Weight: 363.275
• Mol file: 849532-11-2.mol

Synonyms:1-(4-bromo-benzenesulfonyl)-4-(2-methoxy-ethyl)-piperazine;1-[(4-bromophenyl)sulfonyl]-4-(2-methoxyethyl)piperazine;

Chemical Property of Piperazine, 1-[(4-bromophenyl)sulfonyl]-4-(2-methoxyethyl)-

Chemical Property:

• Melting Point: 93 °C
• PSA: 58.23000
• LogP: 2.35840

Purity/Quality:

1-((4-Bromophenyl)sulfonyl)-4-(2-methoxyethyl)piperazine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Piperazine, 1-[(4-bromophenyl)sulfonyl]-4-(2-methoxyethyl)-

There total 3 articles about Piperazine, 1-[(4-bromophenyl)sulfonyl]-4-(2-methoxyethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-(2-methoxyethyl)piperazine (13484-40-7) + 4-bromobenzenesulfonyl chloride (98-58-8) → 1-(4-bromo-benzene-sulfonyl)-4-(2-methoxy-ethyl)piperazine (849532-11-2)

Guidance literature:

1-(2-methoxyethyl)piperazine; 4-bromobenzenesulfonyl chloride; In dichloromethane; at 20 ℃; for 3h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield: 58.0%

1,4-diaza-bicyclo[2.2.2]octane (280-57-9,88935-43-7) + sodium methylate (124-41-4) + 4-bromobenzenesulfonyl chloride (98-58-8) → 1-(4-bromo-benzene-sulfonyl)-4-(2-methoxy-ethyl)piperazine (849532-11-2)

Guidance literature:

1,4-diaza-bicyclo[2.2.2]octane; 4-bromobenzenesulfonyl chloride; In acetonitrile; at 90 ℃; for 4h; Schlenk technique;

sodium methylate; With potassium carbonate; In water; acetonitrile; at 90 ℃; for 4h; Schlenk technique;

DOI:10.1002/open.201800251

Reference yield:

→ 1-(4-bromo-benzene-sulfonyl)-4-(2-methoxy-ethyl)piperazine (849532-11-2)

Guidance literature:

upstream raw materials:

1-(2-methoxyethyl)piperazine

4-bromobenzenesulfonyl chloride

1,4-diaza-bicyclo[2.2.2]octane

sodium methylate

Refernces

• 1、 -. "IMIDAZOLYL-SUBSTITUTED BENZOPHENONE COMPOUNDS". Page/Page column 33-34. . Retrieved 2008/06/13.
• 2、 -. "NEW PYRIMIDINE DERIVATIVES AND THEIR USE IN THERAPY AS WELL AS THE USE OF PYRIMIDINE DERIVATIVES IN THE MANUFACTURE OF A MEDICAMENT FOR PREVENTION AND/OR TREATMENT OF ALZHEIMER’S DISEASE". Page/Page column 99; 51. . Retrieved 2008/06/13.