Etamsylate

Base Information

• Chemical Name: Etamsylate
• CAS No.: 2624-44-4
• Molecular Formula: C6H6O5S^.C4H11N
• Molecular Weight: 263.315
• Hs Code.: 2921199090
• European Community (EC) Number: 220-090-7
• UNII: 24YL531VOH
• DSSTox Substance ID: DTXSID4045559
• Wikipedia: Etamsylate
• Wikidata: Q2000876
• NCI Thesaurus Code: C171814
• RXCUI: 4112
• ChEMBL ID: CHEMBL1514715
• Mol file: 2624-44-4.mol

Synonyms:Dicynone;Benzenesulfonic acid, 2,5-dihydroxy-, compd. with N-ethylethanamine(1:1);E 141;Etamsylate (JAN);Diidroxi-1,4-benzenesulfonato-3-di-etilammonium [Italian];Etamsilato [INN-Spanish];2,5-Dihydroxybenzenesulfonic acid compound with diethylamine (1:1);Altodor;Biosinon;1-Hydroxy-4-oxo-2,5-cyclohexadiene-1-sulfonic acid compd. with diethylamine;Etamsylate B.P.;Etamsylate(Injection Grade);

Chemical Property of Etamsylate

Chemical Property:

• Appearance/Colour: Powder
• Vapor Pressure: 1.13E-10mmHg at 25°C
• Melting Point: 127-131 °C
• Refractive Index: 1.5060 (estimate)
• Boiling Point: 496.4 °C at 760 mmHg
• Flash Point: 254 °C
• PSA: 115.24000
• Density: 1.3441 (rough estimate)
• LogP: 2.43200
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: Very soluble in water, freely soluble in methanol, soluble in anhydrous ethanol, practically insoluble in methylene chloride.
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 263.08274382
• Heavy Atom Count: 17
• Complexity: 252

Purity/Quality:

99% ^*data from raw suppliers

Ethamsylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCNCC.C1=CC(=C(C=C1O)S(=O)(=O)O)O
• Recent EU Clinical Trials: International, multicenter, randomised, blind, sham-controlled, 2x2 cross over phase III clinical trial to assess the efficacy and security of an intravitreal injection of Etamsylate in the improvement of visual acuity of patients with dry age-related macular degeneration.
• Uses: Haemostatic / Anti Coagulant Hemostatic. Hemostatic;prostaglandin synthesis inhibitor
• Clinical Use: Short-term treatment of blood loss in menorrhagiaProphylaxis of surgical bleeding (unlicensed)
• Drug interactions: Potentially hazardous interactions with other drugs None known

Technology Process of Etamsylate

There total 3 articles about Etamsylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

dobesilate (88-46-0) + diethylamine (109-89-7) → ethamsylate (2624-44-4)

Guidance literature:

In cyclohexane; at 65 - 70 ℃; Solvent; Temperature;

Reference yield:

benzene-1,4-diyl diacetate (1205-91-0) → ethamsylate (2624-44-4)

Guidance literature:

Multi-step reaction with 3 steps

1: chlorosulfonic acid / 1,2-dichloro-ethane / 2.5 h / 5 - 90 °C

2: sodium hydroxide; water / 2 h / 40 °C

3: ethanol / 1.5 h / 25 °C

With chlorosulfonic acid; water; sodium hydroxide; In ethanol; 1,2-dichloro-ethane;

Reference yield:

→ ethamsylate (2624-44-4)

Guidance literature:

+*-, 1,4-(HO)2-C6H4;

upstream raw materials:

dobesilate

diethylamine

benzene-1,4-diyl diacetate

Refernces

• 1、 -. "Method for producing high-purity etamsylate". Paragraph 0025; 0029-0036. . Retrieved 2019/03/29.