1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL

Base Information

• Chemical Name: 1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL
• CAS No.: 59767-24-7
• Molecular Formula: C14H13ClO
• Molecular Weight: 232.71
• Hs Code.: 2906299090
• Mol file: 59767-24-7.mol

Synonyms:Benzhydrol, 4-chloro-α-methyl- (6CI);(p-Chlorophenyl)methylphenylcarbinol;1-(4-Chlorophenyl)-1-phenylethanol;1-(p-Chlorophenyl)-1-phenylethanol;4-Chloro(a-methyl-α-phenyl)benzenemethanol;EGIS5927;p-Chloro-α-methylbenzhydrol;

Chemical Property of 1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL

Chemical Property:

• Boiling Point: 358.237 °C at 760 mmHg
• PKA: 13.41±0.29(Predicted)
• Flash Point: 170.456 °C
• PSA: 20.23000
• Density: 1.189 g/cm³
• LogP: 3.59580
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99.9% ^*data from raw suppliers

1-(4-Chlorophenyl)-1-phenylethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-(4-Chlorophenyl)-1-phenylethanol (Clemastine EP Impurity C) is used in the synthetic preparation of rhodium-catalyzed arylation of nitriles, ketones and imines with tetrafluoroborate or arylboronic acids

Technology Process of 1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL

There total 26 articles about 1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

sodium tetraphenyl borate (143-66-8) + para-chloroacetophenone (99-91-2) → 1-(4-chloro-phenyl)-1-phenyl-ethanol (59767-24-7)

Guidance literature:

With chloro(η⁴-1,5-cyclooctadiene){1,3-bis(4-methylbenzyl)perhydrobenzimidazolin-2-ylidene}rhodium(I); ammonium chloride; In o-xylene; at 120 ℃; for 25h; Reagent/catalyst; Schlenk technique;

DOI:10.3987/COM-14-13092

Reference yield: 95.0%

(4-chlorphenyl)magnesium bromide (873-77-8) + acetophenone (98-86-2) → 1-(4-chloro-phenyl)-1-phenyl-ethanol (59767-24-7)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 0.55h; Inert atmosphere;

DOI:10.1016/j.tet.2010.02.078

Reference yield: 95.0%

para-chloroacetophenone (99-91-2) + phenyltriisopropoxytitanium(IV) (16635-23-7) → 1-(4-chloro-phenyl)-1-phenyl-ethanol (59767-24-7)

Guidance literature:

In diethyl ether; for 5h; -20 deg C to r.t.;

DOI:10.1055/s-1991-26429

upstream raw materials:

1-(p-chlorophenyl)ethyl alcohol

methylmagnesium chloride

4-chlorobenzophenone

methanol

Downstream raw materials:

1-{2-[1-(4-chloro-phenyl)-1-phenyl-ethoxy]-ethyl}-piperidine

4-{2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl}-1-(ethoxycarbonyl)piperazine

(R)-2-[2-[1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine

1-(4-chlorophenyl)-1-phenylethene

Refernces

• 1、 An, Yue,Chen, Bo,Gao, Shuang,Huang, Guanwang,Luo, Huihui,Shang, Sensen,Wang, Lianyue. "Isopropanol as a hydrogen source for single atom cobalt-catalyzed Wacker-type oxidation". . p. 2769 - 2773. Retrieved 2020/06/17.
• 2、 Pieterse, Tanya,Visser, Melanie,Marais, Charlene,Bezuidenhoudt, Barend C. B.. "Al(OTf)3: An efficient lewis acid additive for domino addition-elimination of Grignard reagents to activated ketones". supporting information. p. 1541 - 1546. Retrieved 2016/06/14.