2-(2-Methoxyethoxy)ethyl chloride

Base Information

• Chemical Name: 2-(2-Methoxyethoxy)ethyl chloride
• CAS No.: 52808-36-3
• Molecular Formula: C5H11 Cl O2
• Molecular Weight: 138.594
• Hs Code.: 2909199090
• European Community (EC) Number: 855-841-3
• NSC Number: 9056
• UNII: H879VVT5E7
• DSSTox Substance ID: DTXSID6068808
• Nikkaji Number: J429.195F
• Wikidata: Q72489786
• Mol file: 52808-36-3.mol

Synonyms:1-Chloro-2-(2-methoxyethoxy)ethane;1-Chloro-3,6-dioxaheptane; 2-(2-Chloroethoxy)ethyl methyl ether;2-(2-Methoxyethoxy)ethyl chloride; 2-Chloroethyl 2-methoxyethyl ether;3,6-Dioxaheptyl chloride; Ethylene glycol 2-chloroethyl ether methyl ether; NSC9056

Chemical Property of 2-(2-Methoxyethoxy)ethyl chloride

Chemical Property:

• Vapor Pressure: 3.8mmHg at 25°C
• Boiling Point: 156°Cat760mmHg
• Flash Point: 44.8°C
• PSA: 18.46000
• Density: 1.025g/cm³
• LogP: 0.88820
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 138.0447573
• Heavy Atom Count: 8
• Complexity: 41.4

Purity/Quality:

99% ^*data from raw suppliers

1-Chloro-2-(2-methoxyethoxy)ethane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCCOCCCl
• Uses: 1-Chloro-2-(2-methoxyethoxy)ethane is a useful reactant in organic synthesis.

Technology Process of 2-(2-Methoxyethoxy)ethyl chloride

There total 5 articles about 2-(2-Methoxyethoxy)ethyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-(2-methoxyethoxy)ethyl alcohol (111-77-3,95507-80-5) → 1-chloro-2-(2-methoxyethoxy)ethane (52808-36-3)

Guidance literature:

With pyridine; thionyl chloride; In dichloromethane; for 14h; Inert atmosphere; Reflux;

DOI:10.1039/C6NJ01626J

Reference yield: 51.0%

toluene-4-sulfonic acid 2-(2-methoxyethoxy)ethyl ester (50586-80-6,58320-73-3) → 1-chloro-2-(2-methoxyethoxy)ethane (52808-36-3)

Guidance literature:

With ammonium chloride; In dimethyl sulfoxide; at 80 ℃; for 5h;

DOI:10.1016/j.tetlet.2007.05.081

Reference yield:

sodium methylate (124-41-4) + 3-oxa-1,5-dichloropentane (111-44-4) → 1-chloro-2-(2-methoxyethoxy)ethane (52808-36-3)

Guidance literature:

upstream raw materials:

2-(2-methoxyethoxy)ethyl alcohol

sodium methylate

3-oxa-1,5-dichloropentane

toluene-4-sulfonic acid 2-(2-methoxyethoxy)ethyl ester

Downstream raw materials:

Tris(3,6-dioxaheptyl)amine

4-[2-(2-methoxyethoxy)ethoxy]benzaldehyde

3-bromo-5-(2-(2-methoxyethoxy)ethoxy)pyridine

methyl 3,4,5-tris(2-(2-methoxyethoxy)ethoxy)benzoate

Refernces

• 1、 Sinta,Smid. "". . p. 339. Retrieved 1980.
• 2、 Zhang, Guodong,Li, Jiayun,Yang, Chuang,Niu, Congbai,Bai, Ying,Liu, Yu,Peng, Jiajian. "Synthesis of novel poly(ethylene glycol)-containing imidazolium-functionalized phosphine ligands and their application in the hydrosilylation of olefins". . . Retrieved 2018/02/27.