5-Benzofuranol,6-methoxy-2-methyl-3-phenyl-

Base Information

• Chemical Name: 5-Benzofuranol,6-methoxy-2-methyl-3-phenyl-
• CAS No.: 78134-83-5
• Molecular Formula: C16H14 O3
• Molecular Weight: 254.285
• Mol file: 78134-83-5.mol

Synonyms:Isoparvifuran

Chemical Property of 5-Benzofuranol,6-methoxy-2-methyl-3-phenyl-

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Benzofuranol,6-methoxy-2-methyl-3-phenyl-

There total 7 articles about 5-Benzofuranol,6-methoxy-2-methyl-3-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-(benzyloxy)-6-methoxy-2-methyl-3-phenylbenzofuran (1435914-15-0) → 2-methyl-3-phenyl-5-hydroxy-6-methoxy benzofuran (78134-83-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; at 20 ℃; for 1.5h; regiospecific reaction;

DOI:10.1016/j.tet.2013.04.023

Reference yield:

3-(2,4-dimethoxy-5-hydroxyphenyl)-3-phenyl prop-2-ene (52811-32-2) → 2-methyl-3-phenyl-5-hydroxy-6-methoxy benzofuran (78134-83-5)

Guidance literature:

With air; rose bengal; In tetrachloromethane; for 48h; Irradiation;

DOI:10.1016/S0040-4020(01)82062-7

Reference yield:

4-benzyloxy-3-methoxyphenol (40232-88-0) → 2-methyl-3-phenyl-5-hydroxy-6-methoxy benzofuran (78134-83-5)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / toluene / 30 h / 20 °C

2: potassium hydroxide / ethanol; water / 20 °C

3: calcium oxide; sodium hydroxide / N,N-dimethyl acetamide / 4 h / Reflux

4: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 1.5 h / 20 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; potassium hydroxide; sodium hydroxide; calcium oxide; In tetrahydrofuran; ethanol; N,N-dimethyl acetamide; water; toluene;

DOI:10.1016/j.tet.2013.04.023

upstream raw materials:

3-(2,4-dimethoxy-5-hydroxyphenyl)-3-phenyl prop-2-ene

(2-nitroethenyl)benzene

4-benzyloxy-3-methoxyphenol

ethyl 2-(5-(benzyloxy)-6-methoxy-3-phenylbenzofuran-2-yl)acetate

Refernces

• 1、 Walia, S.,Kulshrestha, S.K.,Mukerjee, S.K.. "PHOTOCHEMISTRY OF LATIFOLIN AND SOME RELATED COMPOUNDS". . p. 4817 - 4826. Retrieved 2007/10/02.