Technology Process of bicyclo[4.1.1]octane
There total 4 articles about bicyclo[4.1.1]octane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
diethyl ether;
for 6h;
under 750.06 Torr;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 89 percent / acetonitrile / 72 h / 80 °C
2: 69 percent / LiAlH4 / diethyl ether / 1) 20 deg C, 24 h, 2) reflux, 3 h
3: 43 percent / t-BuLi / diethyl ether; pentane / -78 °C
4: 64 percent / H2 / Pd/C / diethyl ether / 6 h / 750.06 Torr
With
lithium aluminium tetrahydride; hydrogen; tert.-butyl lithium;
palladium on activated charcoal;
In
diethyl ether; acetonitrile; pentane;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 43 percent / t-BuLi / diethyl ether; pentane / -78 °C
2: 64 percent / H2 / Pd/C / diethyl ether / 6 h / 750.06 Torr
With
hydrogen; tert.-butyl lithium;
palladium on activated charcoal;
In
diethyl ether; pentane;
