1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE

Base Information

• Chemical Name: 1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE
• CAS No.: 10394-38-4
• Molecular Formula: C8H9N3
• Molecular Weight: 147.18
• Hs Code.: 2933290090
• Mol file: 10394-38-4.mol

Synonyms:Benzimidazole,5-amino-1-methyl- (6CI,8CI);(1-Methyl-1H-benzimidazol-5-yl)amine;1-Methyl-5-aminobenzimidazole;5-Amino-1-methyl-1H-benzimidazole;5-Amino-1-methylbenzimidazole;NSC 240760;1-Methyl-1H-benzimidazol-5-amine;

Chemical Property of 1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 4.97E-05mmHg at 25°C
• Melting Point: 158-159 °C
• Refractive Index: 1.667
• Boiling Point: 348.6 °C at 760 mmHg
• PKA: 6.35±0.10(Predicted)
• Flash Point: 164.6 °C
• PSA: 43.84000
• Density: 1.27 g/cm³
• LogP: 1.73670
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

1-Methylbenzoimidazol-5-amine 95% ^*data from reagent suppliers

Safty Information:

• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Methyl-5-aminobenzimidazole is used in the synthesis of usnic acid derivatives as tau-aggregation and neuroinflammation inhibitor.

Technology Process of 1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE

There total 12 articles about 1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-methyl-5-nitro-1H-benzo[d]imidazole (5381-78-2) → 1-methyl-1H-benzo[d]imidazol-5-amine (10394-38-4)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 18h;

Reference yield: 47.4%

N-(diphenylmethylene)-1-methyl-1H-benzo[d]imidazol-5-amine → 1-methyl-1H-benzo[d]imidazol-5-amine (10394-38-4)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 7h;

Reference yield: 45.0%

1-methyl-6-nitro-1H-benzoimidazole (5381-79-3) + 1-methyl-5-nitro-1H-benzo[d]imidazole (5381-78-2) → 1-methyl-1H-benzo[d]imidazol-5-amine (10394-38-4) + 1-methyl-6-amino-1H-benzo[d]imidazole (26530-93-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 2h;

DOI:10.1016/j.bmc.2013.04.005

upstream raw materials:

1-methyl-5-nitro-1H-benzo[d]imidazole

N₁-methyl-4-nitrobenzene-1,2-diamine

1-methyl-6-nitro-1H-benzoimidazole

1-Methylbenzimidazole

Downstream raw materials:

C₂₃H₂₆N₆O₃

1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((1-methyl-1H-benzo[d]imidazol-5-yl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

2-{[(1-methyl-benzimidazol-5-yl)imino]methyl}phenol

N-(1-methyl-1H-benzimidazol-5-yl)-5-fluoro-1-[(3-fluorophenyl)methyl]-1H-pyrrolo[2,3-b]pyridine-2-carboxamide

Refernces

• 1、 El’chaninov,Aleksandrov. "Fusion of 2-(furan-2-yl)thiazole to 1-methyl-1H-benzimidazole". . p. 547 - 549. Retrieved 2017.
• 2、 -. "Substituted heteroaryl compounds and compositions and uses thereof (by machine translation)". . . Retrieved 2019/06/07.