Entecavir hydrate

Base Information

• Chemical Name: Entecavir hydrate
• CAS No.: 209216-23-9
• Molecular Formula: C12H15N5O3^.H2O
• Molecular Weight: 295.298
• Hs Code.: 29339900
• Mol file: 209216-23-9.mol

Synonyms:Baraclude;6H-Purin-6-one, 2-amino-1,9-dihydro-9-((1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl)-, monohydrate;Intermediates of drug, pesticide and dye;Enticavir;Entecavir hydrate / 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one monohydrate;Entecavir monohydrate;Entecavir API in stock;Entecavir(monohydrate)--Fine Product;

Chemical Property of Entecavir hydrate

Chemical Property:

• Appearance/Colour: White crystalline powder
• Vapor Pressure: 2.15E-18mmHg at 25°C
• Melting Point: >220°
• Boiling Point: 734.2 °C at 760 mmHg
• Flash Point: 397.9 °C
• PSA: 139.28000
• Density: 1.81 g/cm³
• LogP: -0.31090
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
• Solubility.: DMSO (Slightly), Methanol (Sparingly), Water (Slightly, Heated, Sonicated)

Purity/Quality:

99%min ^*data from raw suppliers

Entecavir hydrate ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Description: Entecavir hydrate is a cyclopentylguanosine anti-hepatitis B virus drug.
• Chemical Composition and Structure: Entecavir hydrate is a guanine nucleoside analogue. It's chemical structure includes a cyclopentyl group attached to the guanine base.
• Uses: Entecavir hydrate is used clinically to treat chronic adult hepatitis B with active viral replication, persistent elevation of serum aminotransferase ALT, or histological evidence of active lesions.
• Mechanism of Action: Entecavir hydrate inhibits hepatitis B virus (HBV) polymerase, leading to a decrease in viral replication.
• Pharmacokinetics: Entecavir hydrate can be phosphorylated to its active triphosphate form within cells, with a half-life of approximately 15 hours.

Technology Process of Entecavir hydrate

There total 1 articles about Entecavir hydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ entecavir monohydrate (209216-23-9)

Guidance literature:

Refernces

• 1、 -. "Low dose entecavir formulation and use". . . Retrieved 2008/06/13.