(2-hydroxy-5-methylbenzene-1,3-diyl)bis(phenylmethanone)

Base Information

• Chemical Name: (2-hydroxy-5-methylbenzene-1,3-diyl)bis(phenylmethanone)
• CAS No.: 77347-19-4
• Molecular Formula: C21H16 O3
• Molecular Weight: 316.356
• Mol file: 77347-19-4.mol

Synonyms:Methanone,(2-hydroxy-5-methyl-1,3-phenylene)bis[phenyl- (9CI); p-Cresol, 2,6-dibenzoyl-(6CI,7CI); 2,6-Dibenzoyl-4-methylphenol; 4-Methyl-2,6-dibenzoylphenol; NSC409657

Chemical Property of (2-hydroxy-5-methylbenzene-1,3-diyl)bis(phenylmethanone)

Chemical Property:

• Vapor Pressure: 1.01E-09mmHg at 25°C
• Boiling Point: 477°C at 760 mmHg
• Flash Point: 256.4°C
• Density: 1.215g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-hydroxy-5-methylbenzene-1,3-diyl)bis(phenylmethanone)

There total 14 articles about (2-hydroxy-5-methylbenzene-1,3-diyl)bis(phenylmethanone) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

Benzoylformic acid (611-73-4) + N-(4-methylphenoxy)acetamide → 2,6-dibenzoyl-4-methylphenol (77347-19-4)

Guidance literature:

With dipotassium peroxodisulfate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate; silver carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 24h; Sealed tube;

DOI:10.1002/ejoc.201900242

Reference yield: 80.0%

2-benzoyl-4-methylphenyl benzoate (344563-86-6) → 2,6-dibenzoyl-4-methylphenol (77347-19-4)

Guidance literature:

With Montmorillonite K 10 clay; microwave irradiation;

DOI:10.1016/j.bmcl.2004.08.014

Reference yield: 65.0%

2-Hydroxy-5-methylisophthalaldehyde (7310-95-4) + phenylboronic acid (98-80-6) → 2,6-dibenzoyl-4-methylphenol (77347-19-4)

Guidance literature:

With oxygen; sodium hydrogencarbonate; palladium(II) chloride benzonitrile complex; copper dichloride; In N,N-dimethyl-formamide; at 60 ℃; for 16h; under 760.051 Torr;

DOI:10.1016/j.tetlet.2010.02.166

upstream raw materials:

p-cresol

Benzotrichlorid

2-hydroxy-5-methylbenzophenone

2-benzoyl-4-methylphenyl benzoate

Downstream raw materials:

2-acetoxy-1,3-dibenzoyl-5-methyl-benzene

Refernces

• 1、 Weng, Fei,Wang, Chengming,Xu, Bin. "Direct C-H bond arylation of 2-hydroxybenzaldehydes with arylboronic acids via ligand-free palladium catalysis". supporting information; experimental part. p. 2593 - 2596. Retrieved 2010/07/04.
• 2、 Kotali,Glaveri,Pavlidou,Tsoungas. "A novel and facile synthesis of 1,2,3-triacylbenzenes". . p. 1172 - 1173. Retrieved 2007/10/02.