1-[3-[3-(4-Chlorophenyl)propoxy]propyl]-piperidinehydrochloride

Base Information

• Chemical Name: 1-[3-[3-(4-Chlorophenyl)propoxy]propyl]-piperidinehydrochloride
• CAS No.: 903576-44-3
• Molecular Formula: C17H26ClNO.ClH
• Molecular Weight: 332.30800
• Mol file: 903576-44-3.mol

Synonyms:Pitolisant hydrochloride;Ciproxidine;Piperidine,1-[3-[3-(4-chlorophenyl)propoxy]propyl]-,hydrochloride;

Chemical Property of 1-[3-[3-(4-Chlorophenyl)propoxy]propyl]-piperidinehydrochloride

Chemical Property:

• PSA: 12.47000
• LogP: 4.90510
• Storage Temp.: Desiccate at RT
• Solubility.: ≥16.6 mg/mL in DMSO; ≥57.4 mg/mL in H2O; ≥94.2 mg/mL in EtOH

Purity/Quality:

99% ^*data from raw suppliers

BF 2649 hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Pitolisant hydrochloride, a first-in-class inverse agonist of the histamine H3 receptor, was approved in the EU for the treatment of excessive daytime sleepiness (EDS) in adults with narcolepsy with or without cataplexy. The drug, which was developed by Bioprojet and has orphan drug designation in the EU and US, enhances wakefulness by increasing histaminergic neuron activity. With once daily oral administration in the morning, patients taking pitolisant exhibited significantly reduced EDS versus placebo but not versus modafinil. Plasma levels of the drug are reduced at the end of the day such that its waking effect is minimized at night (plasma t1/2 10-12 h). Several articles have been published detailing the discovery of pitolisant.
• Uses: BF 2649 Hydrochloride, is a novel histamine H3 receptor antagonist and inverse agonist.