cholesteryl phosphate

Base Information

• Chemical Name: cholesteryl phosphate
• CAS No.: 4358-16-1
• Molecular Formula: C27H47O4P
• Molecular Weight: 466.642
• Mol file: 4358-16-1.mol

Synonyms:Phosphorsaeure-monocholesterylester;3β-Phosphonooxy-cholesten-(5);Cholesteryl-dihydrogenphosphat;cholesteryl dihydrogenphosphate;

Chemical Property of cholesteryl phosphate

Chemical Property:

• Vapor Pressure: 1.84E-14mmHg at 25°C
• Boiling Point: 569.6°Cat760mmHg
• Flash Point: 298.3°C
• PSA: 76.57000
• Density: 1.11g/cm³
• LogP: 7.50570

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of cholesteryl phosphate

There total 13 articles about cholesteryl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

Phosphoric acid (3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester bis-(9H-fluoren-9-ylmethyl) ester (197709-14-1) → cholesteryl phosphate (4358-16-1)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; for 5h; Ambient temperature;

DOI:10.1016/S0040-4039(97)85781-4

Reference yield: 74.0%

cholesterol (57-88-5) → cholesteryl phosphate (4358-16-1)

Guidance literature:

With (1,2-dibromo-1-phenyl-ethyl)-phosphonic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 15h;

DOI:10.1021/jo00157a005

Reference yield:

chloroform (67-66-3,8013-54-5) + cholesterol (57-88-5) + ethyl metaphosphate (4697-37-4) → ethyl phosphate (1623-14-9) + 3-ethylcholesterol (986-19-6) + cholesteryl phosphate (4358-16-1)

Guidance literature:

Behandeln des in Aether geloesten Reaktionsprodukts mit Wasser;

upstream raw materials:

chloroform

cholesterol

ethyl metaphosphate

cholesteryl-dichloro phosphate

Downstream raw materials:

cholesterol propyl ether

3,5-cholestadiene

cholesteryl methyl ether

Refernces

• 1、 Ociepa, Micha?,Knouse, Kyle W.,He, David,Vantourout, Julien C.,Flood, Dillon T.,Padial, Natalia M.,Chen, Jason S.,Sanchez, Brittany B.,Sturgell, Emily J.,Zheng, Bin,Qiu, Shenjie,Schmidt, Michael A.,Eastgate, Martin D.,Baran, Phil S.. "Mild and Chemoselective Phosphorylation of Alcohols Using a Ψ-Reagent". supporting information. p. 9337 - 9342. Retrieved 2021/10/01.
• 2、 Okamoto, Yoshiki. "Synthesis of Alkyl Dihydrogenphosphate by the Reaction of Alcohols and Silyl Polyphosphate". . p. 3393 - 3394. Retrieved 2007/10/02.