Benzeneacetic acid, 2-methyl-, 2-propynyl ester

Base Information

• Chemical Name: Benzeneacetic acid, 2-methyl-, 2-propynyl ester
• CAS No.: 90705-93-4
• Molecular Formula: C12H12O2
• Molecular Weight: 188.226
• Mol file: 90705-93-4.mol

Synonyms:

Chemical Property of Benzeneacetic acid, 2-methyl-, 2-propynyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzeneacetic acid, 2-methyl-, 2-propynyl ester

There total 1 articles about Benzeneacetic acid, 2-methyl-, 2-propynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

o-methylphenylacetic acid (644-36-0) + propargyl alcohol (107-19-7) → C12H12O2 (90705-93-4)

Guidance literature:

With β-cyclodextrin-SO3H; In neat (no solvent); at 70 ℃; for 4h;

DOI:10.1039/c4ra16699j

Reference yield: 74.0%

C12H12O2 (90705-93-4) + 5'-azido-5'-deoxy-2',3'-O-isopropylideneuridine (15083-05-3) → 5'-deoxy-2',3'-O-(1-methylethylidene)-5'-{4-[(2-methylphenyl)acetoxymethyl]-1,2,3-triazol-1-yl}uridine (1152593-90-2)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium ascorbate; In water; tert-butyl alcohol; at 28 ℃;

DOI:10.1016/j.bmc.2009.02.019

upstream raw materials:

o-methylphenylacetic acid

propargyl alcohol

Downstream raw materials:

5'-deoxy-2',3'-O-(1-methylethylidene)-5'-{4-[(2-methylphenyl)acetoxymethyl]-1,2,3-triazol-1-yl}uridine

Refernces

• 1、 Chaudhary, Preeti M.,Chavan, Sayalee R.,Shirazi, Fazal,Razdan, Meenakshi,Nimkar, Prachi,Maybhate, Shailaja P.,Likhite, Anjali P.,Gonnade, Rajesh,Hazara, Braja G.,Deshpande, Mukund V.,Deshpande, Sunita R.. "Exploration of click reaction for the synthesis of modified nucleosides as chitin synthase inhibitors". body text. p. 2433 - 2440. Retrieved 2009/09/05.