Calcium Acetate

Base Information

• Chemical Name: Calcium Acetate
• CAS No.: 62-54-4
• Molecular Formula: C4H6CaO4
• Molecular Weight: 158.167
• Hs Code.: 29152990
• European Community (EC) Number: 200-540-9
• ICSC Number: 1092
• UNII: Y882YXF34X
• DSSTox Substance ID: DTXSID0020234
• Nikkaji Number: J4.823B
• Wikipedia: Calcium acetate,Calcium_acetate
• Wikidata: Q409251
• NCI Thesaurus Code: C47429
• RXCUI: 214342
• ChEMBL ID: CHEMBL1200800
• Mol file: 62-54-4.mol

Synonyms:acetic acid, calcium salt;acetic acid, calcium salt (2:1);calcium acetate;Phoslo

Chemical Property of Calcium Acetate

Chemical Property:

• Appearance/Colour: white crystals or powder
• Melting Point: 160 °C (dec.)
• Refractive Index: 1.5500
• Boiling Point: 117.1 °C at 760 mmHg
• Flash Point: 40 °C
• PSA: 52.60000
• Density: 1.5 g/cm³
• LogP: 0.02760
• Storage Temp.: Hygroscopic, Room Temperature, under inert atmosphere
• Solubility.: H2O: 1 M at 20 °C, clear, colorless
• Water Solubility.: soluble
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 157.9891995
• Heavy Atom Count: 9
• Complexity: 25.5

Purity/Quality:

99% ^*data from raw suppliers

Calcium Acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Metals -> Organic Acids, Metal Salts
• Canonical SMILES: CC(=O)[O-].CC(=O)[O-].[Ca+2]
• Recent ClinicalTrials: Acetate and Age-associated Arterial Dysfunction
• Recent EU Clinical Trials: An Open-label, Randomised, Active-controlled, Parallel Group, Multicentre, Phase 3 Study to Investigate the Safety and Efficacy of PA21 (Velphoro?) and Calcium Acetate (Phoslyra?) in Paediatric and Adolescent CKD Patients with Hyperphosphataemia
• Inhalation Risk: A nuisance-causing concentration of airborne particles can be reached quickly when dispersed.
• Effects of Short Term Exposure: The substance is irritating to the eyes, skin and respiratory tract.
• Uses: Calcium acetate [Ca(CH3COO)2.H2O] is used as a food additive and a mordant to fix dyes in the textile industry. It is used as an alkali (base) in the manufacture of soaps, to improve some lubricants, and as an antimold to preserve baked goods for a longer shelf life. Calcium Acetate is the calcium salt of acetic acid which functions as a sequestrant and mold control agent. it contains approximately 25% calcium. it is a white odorless powder which is readily soluble in water with a solubility of approximately 37 g in 100 g water at 0°c. its solubility decreases with increasing temperature, with a sol- ubility of approximately 29 g in 100 g of water at 100°c. Calcium Acetate is the salt of acetic acid which is used as a preservative and sequestrant. Calcium Acetate is a salt of acetic acid (A167640), a common chemical reagent used in a multitude of organic reactions. It is the primary constituent of vinegar, contributing to its distinct taste and odor. It is used in the synthesis of dye-sensitized solar cells.
• Production method: It is obtained by the reaction between calcium carbonate and acetic acid. Preparation method of anhydrous calcium acetate: the refined powder of calcium carbonate is added to the water, stirred into a suspension; added separately of a small amount of glacial acetic acid. After completion of the reaction, the filtrate was concentrated in a water bath and a white solid, anhydrous calcium acetate, was precipitated from the viscous filtrate. It is obtained by the neutralization between coke acid (wood acetic acid) and calcium hydroxide, followed by the evaporation of the filtrate and recrystallization. It is obtained by the reaction between the reaction between acetic acid and calcium hydroxide or calcium carbonate. Filter, concentrate and cool to obtain the dihydrate (colorless crystal), heated to 84 °C in a water salt (colorless crystal), heated to 100 °C to obtain the anhydrous salt. Shellfish can be taken as raw materials, washed, crushed and dried for 1 h, subjecting to barbecue for 2 hour at 900~l000 ℃, then being added water to make a 1.3~1.5mol/L lime milk. And then neutralized with acetic acid to clarify, filter with the filtrate concentrated, and finally dried at 120~140 °C to get the final product with a yield of 91.28%. To a 20% acetic acid solution, add calcium carbonate powder to until there is no longer any CO2 gas escaping, then add a small amount of calcium carbonate, heated? 80 ° C for reaction of 2-3h. The filtrate was heated and concentrated with water bath while adding a small amount of 80% acetic acid at the same time to precipitate the calcium acetate monohydrate (what precipitated after the cooling of the solution is dihydrate), and finally dried at 60~70 ℃to derive the products.
• Description: Calcium acetate is a chemical compound which is calcium salt of acetic acid. It has the formula Ca(C2H3O2)2. Its standard name is calcium acetate, while calcium ethanoate is the systematic name. An older name is acetate of lime. The anhydrous form is very hygroscopic; therefore the monohydrate (Ca(CH3COO)2?H2O) is the common form.
• Clinical Use: Phosphate binding agent

Technology Process of Calcium Acetate

There total 30 articles about Calcium Acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

acetic acid (64-19-7,77671-22-8) → calcium acetate (62-54-4)

Guidance literature:

With calcium carbonate; In water;

DOI:10.1016/j.jssc.2018.10.041

Reference yield: 91.0%

→ calcium diformate (544-17-2) + calcium acetate (62-54-4)

Guidance literature:

Reference yield: 71.0%

calcium(II) nitrate tetrahydrate + acetic anhydride (108-24-7) → calcium acetate (62-54-4)

Guidance literature:

In acetic anhydride; byproducts: NO2, Ca(NO3)2; heating a clear soln. of 6 g Ca(NO3)2*4H2O and 30 ml acetic anhydride; pptn.;; storage for some time in 96% ethanol, to remove Ca(NO3)2; sucking off; dehydration by 2 h heating in vac. at 130°C;;

upstream raw materials:

acetic anhydride

ethyl acetate

acetic acid

lead acetate

Downstream raw materials:

ethyl acetate

1-Phenylbut-1-en-3-one

Dehydracetic acid

acetone

Refernces

• 1、 Deb,Baruah,Dass. "Synthesis, characterization and the thermal decomposition of calcium(II)bis(oxalato)calcium(II)dihydrate". . p. 301 - 308. Retrieved 1996.
• 2、 -. "DIRECT CONVERSION OF ESTERS TO CARBOXYLATES". Paragraph 0041. . Retrieved 2022/03/22.
• 3、 -. "RECOVERY OF ORGANIC ACID USING A COMPLEX EXTRACTION SOLVENT". Page/Page column 34-35. . Retrieved 2012/05/05.