1,2-Dichloro-1,2-difluoroethane

Base Information

• Chemical Name: 1,2-Dichloro-1,2-difluoroethane
• CAS No.: 431-06-1
• Molecular Formula: C2H2 Cl2 F2
• Molecular Weight: 134.941
• Hs Code.: 2903791090
• European Community (EC) Number: 207-070-3
• DSSTox Substance ID: DTXSID70861928
• Nikkaji Number: J85.962A
• Mol file: 431-06-1.mol

Synonyms:1,2-Dichloro-1,2-difluoroethane;431-06-1;C2H2Cl2F2;EINECS 207-070-3;HCFC-132;Ethane, 1,2-dichloro-1,2-difluoro-;SCHEMBL201983;1,2-difluor-1,2-dichlorethan;DTXSID70861928;1,2-Difluoro-1,2-dichloroethane;1,2-dichloro-1,2-difluoro-ethane;MFCD00045245;AKOS006227825;LS-185335;FT-0606373;1,2-bis(chloranyl)-1,2-bis(fluoranyl)ethane;A826156

Chemical Property of 1,2-Dichloro-1,2-difluoroethane

Chemical Property:

• Vapor Pressure: 195mmHg at 25°C
• Melting Point: -155°C
• Boiling Point: 58-59°C
• Flash Point: °C
• PSA: 0.00000
• Density: 1.416g/cm³
• LogP: 2.05520
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 133.9501618
• Heavy Atom Count: 6
• Complexity: 34.5

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(F)Cl)(F)Cl

Technology Process of 1,2-Dichloro-1,2-difluoroethane

There total 27 articles about 1,2-Dichloro-1,2-difluoroethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1,2-Dichloroethylene (540-59-0,43695-79-0) → 1,2-difluoro-1,2-dichloroethene (431-06-1)

Guidance literature:

With hydrogen fluoride; fluorine; at -45 ℃; for 4h; Inert atmosphere;

Reference yield: 83.0%

threo-1-bromo-2-fluoro-1,2-dichloroethane (430-88-6,55159-50-7,55159-51-8) → 1,2-difluoro-1,2-dichloroethene (431-06-1)

Guidance literature:

With bromine trifluoride; In various solvent(s); at 10 - 20 ℃; for 4h;

Reference yield: 62.0%

cis-1,2-Dichloroethylene (156-59-2,43695-79-0) → 1,2-difluoro-1,2-dichloroethene (431-06-1) + erythreo-1-bromo-2-fluoro-1,2-dichloroethane (430-88-6,55159-50-7,55159-51-8) + threo-1-bromo-2-fluoro-1,2-dichloroethane (430-88-6,55159-50-7,55159-51-8)

Guidance literature:

With bromine trifluoride; bromine; In 1,1,2-Trichloro-1,2,2-trifluoroethane; at 10 - 20 ℃;

upstream raw materials:

(+/-)-chlorofluoroiodomethane

1,2-difluoroethene

cis-1,2-Dichloroethylene

trans-1,2-dichloroethylene

Downstream raw materials:

1-chloro-1,2-difluoroethene

1,2-difluoroethene

(Z)-1,2-difluoro-ethene

(E)-1,2-difluoroethene

Refernces

• 1、 -. "PROCESS FOR THE FLUORINATION OF HALOOLEFINS". Page/Page column 6. . Retrieved 2012/02/02.
• 2、 Commandeur, Jan N. M.,King, Laurence J.,Koymans, Luc,Vermeulen, Nico P. E.. "Bioactivation of S-(2,2-dihalo-1,1-difluoroethyl)-L-cysteines and S- (trihalovinyl)-L-cysteines by cysteine S-conjugate β-lyase: Indications for formation of both thionoacylating species and thiiranes as reactive intermediates". . p. 1092 - 1102. Retrieved 2007/10/03.