Corydine

Base Information

• Chemical Name: Corydine
• CAS No.: 476-69-7
• Molecular Formula: C20H23 N O4
• Molecular Weight: 341.407
• UNII: 1O1D15OP5R
• DSSTox Substance ID: DTXSID00963883
• Nikkaji Number: J5.978A
• Metabolomics Workbench ID: 138725
• ChEMBL ID: CHEMBL489524
• Mol file: 476-69-7.mol

Synonyms:corydine;corydine hydrochloride;corydine, (R)-isomer

Chemical Property of Corydine

Chemical Property:

• Vapor Pressure: 7.51E-11mmHg at 25°C
• Melting Point: 165-167oC
• Refractive Index: 1.5614 (estimate)
• Boiling Point: 505.7°Cat760mmHg
• PKA: 9.68±0.20(Predicted)
• Flash Point: 259.7°C
• PSA: 51.16000
• Density: 1.222g/cm³
• LogP: 3.10800
• Storage Temp.: 4°C, Inert atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly, Sonicated)
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 341.16270821
• Heavy Atom Count: 25
• Complexity: 475

Purity/Quality:

≥98% ^*data from raw suppliers

Corydine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCC2=CC(=C(C3=C2C1CC4=C3C(=C(C=C4)OC)OC)O)OC
• Isomeric SMILES: CN1CCC2=CC(=C(C3=C2[C@@H]1CC4=C3C(=C(C=C4)OC)OC)O)OC
• Uses: (+)-Corydine is an isoquinoline alkaloid from the tubers of Corydalis cava and has been shown to inhibit acetylcholinesterase in a dose-dependant manner.

Technology Process of Corydine

There total 12 articles about Corydine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

O-acetyl coridine → (6aS)-(+)-corydine (476-69-7)

Guidance literature:

With potassium carbonate; In methanol;

DOI:10.1016/0031-9422(80)80228-7

Reference yield:

corydine (2505-56-8,1221233-47-1,1221347-49-4,1221347-50-7) → (6aS)-(+)-corydine (476-69-7)

Guidance literature:

With tartaric acid;

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + corytuberine (517-56-6,71630-07-4) → (6aS)-(+)-corydine (476-69-7)

Guidance literature:

With diethyl ether;

upstream raw materials:

diazomethane

corytuberine

tartaric acid

corydine

Downstream raw materials:

Corydin-methjodid

corydine hydrochloride

(+)-N-methylcorydinium iodide

Refernces

• 1、 Dwuma-Badu, D.,Ayim, J. S. K.,Rexford, O.,Ateya, A. M.,Slatkin, D. J.,Et Al.. "ALKALOIDS OF KOLOBOPETALIUM AURICULATUM". . p. 1564 - 1565. Retrieved 2007/10/02.