Dimethylsulfamoyl chloride

Base Information

• Chemical Name: Dimethylsulfamoyl chloride
• CAS No.: 13360-57-1
• Molecular Formula: C2H6ClNO2S
• Molecular Weight: 143.594
• Hs Code.: 29299000
• European Community (EC) Number: 236-412-4
• NSC Number: 93875
• UNII: 76BN2B689B
• DSSTox Substance ID: DTXSID6065420
• Nikkaji Number: J23.438I
• Wikidata: Q72472067
• Mol file: 13360-57-1.mol

Synonyms:N,N-dimethylsulfamoyl chloride

Chemical Property of Dimethylsulfamoyl chloride

Chemical Property:

• Appearance/Colour: clear colorless to slightly yellow liquid
• Vapor Pressure: 0.653mmHg at 25°C
• Melting Point: -13 °C
• Refractive Index: n20/D 1.452(lit.)
• Boiling Point: 186.7 °C at 760 mmHg
• PKA: -8.25±0.70(Predicted)
• Flash Point: 94.4 °C
• PSA: 45.76000
• Density: 1.418 g/cm³
• LogP: 1.11240
• Storage Temp.: Store below +30°C.
• Water Solubility.: DECOMPOSES
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 142.9807773
• Heavy Atom Count: 7
• Complexity: 132

Purity/Quality:

99% ^*data from raw suppliers

N,N-Dimethylsulfamoyl chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T+
• Hazard Codes: T+
• Statements: 45-21/22-26-34
• Safety Statements: 53-45

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Toxic Gases & Vapors -> Acid Halides
• Canonical SMILES: CN(C)S(=O)(=O)Cl
• Uses: Dichlorofluanid is a degradation product of the pesticide Dichlorofluanid.

Technology Process of Dimethylsulfamoyl chloride

There total 13 articles about Dimethylsulfamoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

N,N-dimethylammonium chloride (506-59-2) → dimethylamino sulfonyl chloride (13360-57-1)

Guidance literature:

With sulfuryl dichloride; for 12h; Heating;

Reference yield: 70.0%

dimethylchloroamine (1585-74-6) → dimethylamino sulfonyl chloride (13360-57-1)

Guidance literature:

With sulfur dioxide; In tetrachloromethane; 1.) 0 deg C, 1.5 h, 2.) up to r.t., overnight;

Reference yield:

dimethyl amine (124-40-3) → dimethylamino sulfonyl chloride (13360-57-1)

Guidance literature:

With sulfuryl dichloride;

DOI:10.1021/ja01267a004

upstream raw materials:

N,N-dimethylammonium chloride

dimethyl amine

N,N-Dimethylcarbamoyl chloride

Carbamidsaeure-methylester-N-sulfonsaeure-dimethylamid

Downstream raw materials:

N,N-dimethyl-4-(pyrimidin-2-yl)piperazine-1-sulfonamide

tetramethylsulfamide

N,N-dimethyl-N'-(2,4-dimethyl-phenyl)-sulfamide

5-Chlor-1-(dimethylaminosulfonyl)-3-phenyl-1H-indazol

Refernces

• 1、 Tanaka et al.. "-". . p. 1324. Retrieved 1978.
• 2、 Adkison, Kim K.,Barrett, David G.,Deaton, David N.,Gampe, Robert T.,Hassell, Anne M.,Long, Stacey T.,McFadyen, Robert B.,Miller, Aaron B.,Miller, Larry R.,Payne, J. Alan,Shewchuk, Lisa M.,Wells-Knecht, Kevin J.,Willard Jr., Derril H.,Wright, Lois L.. "Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors?". . p. 978 - 983. Retrieved 2007/10/03.
• 3、 Dow, Robert L.,Paight, Ernest S.,Schneider, Steven R.,Hadcock, John R.,Hargrove, Diane M.,Martin, Kelly A.,Maurer, Tristan S.,Nardone, Nancy A.,Tess, David A.,DaSilva-Jardine, Paul. "Potent and selective, sulfamide-based human β3-adrenergic receptor agonists". . p. 3235 - 3240. Retrieved 2007/10/03.