2-Nitro-9-(4-chlorobenzylidene)-9H-fluorene

Base Information

• Chemical Name: 2-Nitro-9-(4-chlorobenzylidene)-9H-fluorene
• CAS No.: 4364-38-9
• Molecular Formula: C₂₀H₁₂ClNO₂
• Molecular Weight: 333.774
• NSC Number: 23171
• Nikkaji Number: J1.379.585A
• Mol file: 4364-38-9.mol

Synonyms:NSC23171;NSC-23171;2-Nitro-9-(4-chlorobenzylidene)-9H-fluorene

Chemical Property of 2-Nitro-9-(4-chlorobenzylidene)-9H-fluorene

Chemical Property:

• Vapor Pressure: 3.33E-09mmHg at 25°C
• Boiling Point: 488.2°Cat760mmHg
• Flash Point: 249°C
• PSA: 45.82000
• Density: 1.391g/cm³
• LogP: 6.34070
• XLogP3: 5.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 333.0556563
• Heavy Atom Count: 24
• Complexity: 506

Purity/Quality:

99% ^*data from raw suppliers

9-(4-CHLOROBENZYLIDENE)-2-NITROFLUORENE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C3=C(C2=CC4=CC=C(C=C4)Cl)C=C(C=C3)[N+](=O)[O-]
• Isomeric SMILES: C1=CC=C\2C(=C1)C3=C(/C2=C/C4=CC=C(C=C4)Cl)C=C(C=C3)[N+](=O)[O-]

Technology Process of 2-Nitro-9-(4-chlorobenzylidene)-9H-fluorene

There total 4 articles about 2-Nitro-9-(4-chlorobenzylidene)-9H-fluorene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-nitro-9H-fluorene (607-57-8) + 4-chlorobenzaldehyde (104-88-1) → 9-(4-chloro-benzylidene)-2-nitro-fluorene (136036-57-2,4364-38-9)

Guidance literature:

With di-(p-methoxyphenyl)tellurium oxide; In acetonitrile; for 1h; Ambient temperature; Irradiation;

DOI:10.1080/00397919708004087

Reference yield: 51.0%

2-nitro-9H-fluorene (607-57-8) + 4-chlorobenzaldehyde (104-88-1) → 9-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-2-nitro-9H-fluorene (4364-38-9)

Guidance literature:

With potassium fluoride on basic alumina; In methanol; at 60 - 70 ℃; for 6h;

DOI:10.1080/00397910008087010

Reference yield:

2-nitro-9H-fluorene (607-57-8) + 4-chlorobenzaldehyde (104-88-1) → 9-(4-chloro-benzylidene)-2-nitro-fluorene (136036-57-2,4364-38-9) + 9-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-2-nitro-9H-fluorene (4364-38-9)

Guidance literature:

With sodium hydroxide; butyltriethylammonium hydrogen sulfate; In tetrahydrofuran; at -4 ℃; for 3.5h; Title compound not separated from byproducts;

DOI:10.1002/(SICI)1097-458X(199807)36:7<520::AID-OMR327>3.0.CO;2-7

upstream raw materials:

2-nitro-9H-fluorene

4-chlorobenzaldehyde

Refernces

• 1、 Annunziata, Rita,Molteni, Valentina,Raimondi, Laura. "Synthesis and structural assignment of 2,4′-disubstituted benzylidenefluorenes and 4′-substituted benzylidene-1-azafluorenes". . p. 520 - 528. Retrieved 2007/10/03.