Dihydromyricetin

Base Information Edit

Chemical Name:Dihydromyricetin
CAS No.:27200-12-0
Molecular Formula:C15H12O8
Molecular Weight:320.255
Hs Code.:29329990
UNII:KD8QND6427
DSSTox Substance ID:DTXSID50181676
Nikkaji Number:J17.065H
Wikipedia:Ampelopsin
Wikidata:Q422305
Metabolomics Workbench ID:51715
ChEMBL ID:CHEMBL3348861
Mol file:27200-12-0.mol

Synonyms:ampelopsin

Suppliers and Price of Dihydromyricetin

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Ampeloptin
10mg
$ 120.00

TCI Chemical
Dihydromyricetin >97.0%(HPLC)
1g
$ 455.00

TCI Chemical
Dihydromyricetin >97.0%(HPLC)
200mg
$ 182.00

Sigma-Aldrich
Dihydromyricetin ≥98% (HPLC)
5mg
$ 73.20

Sigma-Aldrich
Dihydromyricetin analytical standard
10mg
$ 155.00

Sigma-Aldrich
Dihydromyricetin ≥98% (HPLC)
25mg
$ 298.00

Labseeker
Dihydromyricetin 98
1g
$ 367.00

JR MediChem
Dihydromyricetin 98%
20mg
$ 180.00

DC Chemicals
Dihydromyricetin >98%,StandardReferencesGrade
20 mg
$ 280.00

Crysdot
Ampelopsin 98+%
100mg
$ 162.00

Total 213 raw suppliers

Chemical Property of Dihydromyricetin Edit

Chemical Property:

Vapor Pressure:1.16E-25mmHg at 25°C
Melting Point:239-241 °C
Refractive Index:1.798
Boiling Point:780.7 °C at 760 mmHg
PKA:7.38±0.60(Predicted)
Flash Point:296.7 °C
PSA：147.68000
Density:1.808 g/cm³
LogP:0.89190
Storage Temp.:?20°C
Solubility.:DMSO: ≥5mg/mL (warmed)
XLogP3:1.1
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:1
Exact Mass:320.05321734
Heavy Atom Count:23
Complexity:445

Purity/Quality:

60%,98%, ^*data from raw suppliers

Ampeloptin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C=C(C(=C1O)O)O)C2C(C(=O)C3=C(C=C(C=C3O2)O)O)O
Isomeric SMILES:C1=C(C=C(C(=C1O)O)O)[C@@H]2[C@H](C(=O)C3=C(C=C(C=C3O2)O)O)O
Recent ClinicalTrials:Phase I, Dose-Escalation Study of Dihydromyricetin (DHM) to Treat Alcohol-Associated Liver Disease
Description Dihydromyricetin (DHM), also known as ampelopsin, is a natural flavonoid compound, which is found in large quantities in Asian plant species. One of them – Hovenia dulcis – is known for centuries in traditional Chinese medicine as a cure for alcohol poisoning and hangover (Liang et al. 2014). DHM is sold as a supplement and is commonly marketed as a treatment for hangovers due to its ability to reduce blood alcohol levels and projected hepatoprotective properties.Dihydromyricetin had beneficial effects on health such as antimicrobial, anti-inflammatory,antioxidative, anticancer, lipid and glucose metabolism-regulatory activities，and cell death-mediating without or with minimum adverse effects on normal cells. And most importantly, DHM has been shown to provide significant hepatoprotective effects. Its positive influence on alcohol-induced and other liver diseases was suggested in the study of acute liver failure (Liu et al. 2017).
Uses Dihydromyricetin has been used to study its effect on adipogenesis and glucose uptake in differentiated 3T3-L1 pre-adipocytes. It has also been used to study its antitumor activity against liver cancer cells.

Technology Process of Dihydromyricetin

There total 1 articles about Dihydromyricetin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%