4,4'-Methylenediphenol

Base Information

• Chemical Name: 4,4'-Methylenediphenol
• CAS No.: 620-92-8
• Deprecated CAS: 1429425-30-8
• Molecular Formula: > C13H12 O2
• Molecular Weight: 200.237
• Hs Code.: 29072990
• European Community (EC) Number: 210-658-2
• NSC Number: 401136
• UNII: QD2C19044Z
• DSSTox Substance ID: DTXSID9022445
• Nikkaji Number: J6.829B
• Wikipedia: Bisphenol_F
• Wikidata: Q9658061
• Metabolomics Workbench ID: 75080
• ChEMBL ID: CHEMBL138061
• Mol file: 620-92-8.mol

Synonyms:bisphenol F;bisphenol-F;4,4'-bisphenol F;4,4'-methylenebis(phenol);4,4'-methylenebis(phenol), disodium salt;bis(4-hydroxyphenyl)methane;p-hydroxydiphenylmethane

Chemical Property of 4,4'-Methylenediphenol

Chemical Property:

• Appearance/Colour: White powder
• Vapor Pressure: 1.22E-06mmHg at 25°C
• Melting Point: 162-164 °C
• Refractive Index: 1.635
• Boiling Point: 390 °C at 760 mmHg
• PKA: 9.91±0.10(Predicted)
• Flash Point: 192.9 °C
• PSA: 40.46000
• Density: 1.208 g/cm³
• LogP: 2.68860
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Water Solubility.: It is soluble in ethanol, ether, chloroform, alkali; slightly soluble in DMSO, insoluble in carbon disulfide and water.
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 200.083729621
• Heavy Atom Count: 15
• Complexity: 157

Purity/Quality:

98%, ^*data from raw suppliers

BisphenolF ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=CC=C1CC2=CC=C(C=C2)O)O
• Uses: 4,4'-Dihydroxydiphenylmethane, is also used as a bisphenol derivative with antioxidant activities. Bisphenol F has been reported to exhibit estrogen agonistic properties. Bisphenol F is used to make epoxy resins and coatings for various applications, such as lacquers, varnishes, liners, adhesives, plastics, water pipes, dental sealants, and food packaging. Bisphenol F is a bisphenol derivative with antioxidant activities. Bisphenol F has been reported to exhibit estrogen agonistic properties.

Technology Process of 4,4'-Methylenediphenol

There total 51 articles about 4,4'-Methylenediphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

bis(4-hydroxyphenyl)methanol (69552-26-7) → bis-(4-hydroxyphenyl)methane (620-92-8)

Guidance literature:

With o-benzenedisulfonimide; isopropyl alcohol; at 80 ℃; for 3h;

DOI:10.1002/ejoc.200900444

Reference yield: 97.1%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + phenol (108-95-2,27073-41-2) → bis-(4-hydroxyphenyl)methane (620-92-8)

Guidance literature:

With MIL-101(Cr/Al)_A-f; at 60 ℃; for 0.5h; Reagent/catalyst; Kinetics;

DOI:10.1016/j.apcata.2018.04.020

Reference yield: 97.0%

9-fluorenone (486-25-9,952573-42-1) + phenol (108-95-2,27073-41-2) → bis-(4-hydroxyphenyl)methane (620-92-8) + 9,9-bis(4-hydroxyphenyl)fluorene (3236-71-3)

Guidance literature:

With hydrogenchloride; In Zinc chloride; water; isopropyl alcohol;

upstream raw materials:

4,4'-Dihydroxybenzophenone

5,5'-methylenedisalicylic acid

4,4'-diamino diphenyl methane

formaldehyd

Downstream raw materials:

4-[4-(7-bromo-heptyloxy)-benzyl]-phenol

bis(4-acetoxyphenyl)methane

4,4'-bis(carboxymethoxy)diphenylmethane

[4-(4-hydroxy-benzyl)-phenoxy]-acetic acid

Refernces

• 1、 Xia, Xinnian,Xu, Yingzhuang,Chen, You,Liu, Yutang,Lu, Yanbing,Shao, Luhua. "Fabrication of MIL-101(Cr/Al) with flower-like morphology and its catalytic performance". . p. 138 - 145. Retrieved 2018.
• 2、 -. "Iridium catalyst for catalyzing propargyl ester rearrangement to prepare substituted ketone compounds". Paragraph 0077-0080. . Retrieved 2021/02/24.
• 3、 Deota, Pradeep T.,Singh, Deepak. "Eco-friendly Solvent-free Route to Alkyl- and Aryl-Bisphenols Catalyzed by Perchloric Acid-Silica". . p. 1 - 7. Retrieved 2020/07/21.