18-Hydroxycorticosterone

Base Information

• Chemical Name: 18-Hydroxycorticosterone
• CAS No.: 561-65-9
• Molecular Formula: C21H30 O5
• Molecular Weight: 362.466
• European Community (EC) Number: 209-221-9
• UNII: 4U5T0O9SI3
• DSSTox Substance ID: DTXSID80897516
• Nikkaji Number: J188.422K
• Wikipedia: 18-Hydroxycorticosterone
• Wikidata: Q3597767
• Metabolomics Workbench ID: 35395
• Mol file: 561-65-9.mol

Synonyms:18 Hydrocorticosterone;18 Hydroxycorticosterone;18-Hydrocorticosterone;18-Hydroxycorticosterone;Hydroxycorticosterone, 18

Chemical Property of 18-Hydroxycorticosterone

Chemical Property:

• Vapor Pressure: 9.3E-16mmHg at 25°C
• Boiling Point: 577.8°Cat760mmHg
• PKA: 12.98±0.10(Predicted)
• Flash Point: 317.3°C
• PSA: 94.83000
• Density: 1.28g/cm³
• LogP: 1.63910
• Storage Temp.: 2-8°C
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 362.20932405
• Heavy Atom Count: 26
• Complexity: 655

Purity/Quality:

99%, ^*data from raw suppliers

18-HydroxyCorticosterone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)CO)O
• Isomeric SMILES: C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@H]4C(=O)CO)CO)O
• Uses: 18-Hydroxycorticosterone is a derivative of Corticosterone. 18-Hydroxycorticosterone is used as an intermediate in the synthesis of Aldosterone (A514700).

Technology Process of 18-Hydroxycorticosterone

There total 6 articles about 18-Hydroxycorticosterone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Corticosterone (50-22-6) → aldosterone (6251-69-0) + 11β,21-Dihydroxy-3,20-dioxo-pregn-4-en-18-ol (561-65-9)

Guidance literature:

With Krebs-Ringer-bicarbonate-glucose buffer; male CHBB-Thom rat adrenal mitochondria; NADPH; Kinetics; inhib. by cortisol;

DOI:10.1016/0039-128X(94)00064-J

Reference yield:

→ 11β,21-Dihydroxy-3,20-dioxo-pregn-4-en-18-ol (561-65-9)

Guidance literature:

Reference yield:

→ 11β,18,21-trihydroxypregn-4-ene-3,20-dione (561-65-9)

Guidance literature:

Progesteron (i. Nebennierengewebe d. Ochsenfrosches (Rana catesbiana));

DOI:10.1021/ja01509a065

upstream raw materials:

Corticosterone

Downstream raw materials:

11β-Hydroxy-3-oxoandrost-4-ene-17β,18-carbolactone

Refernces

• 1、 Matkovic, Laura,Gomez-Sanchez, Celso E.,Lantos, Carlos P.,Cozza, Eduardo N.. "Inhibition of aldosterone formation by cortisol in rat adrenal mitochondria". . p. 447 - 452. Retrieved 2007/10/02.