Cyclohexanesulfonamide, N-(2-chlorophenyl)-2-oxo-

Base Information

• Chemical Name: Cyclohexanesulfonamide, N-(2-chlorophenyl)-2-oxo-
• CAS No.: 925234-63-5
• Molecular Formula: C12H14ClNO3S
• Molecular Weight: 287.767
• Mol file: 925234-63-5.mol

Synonyms:

Chemical Property of Cyclohexanesulfonamide, N-(2-chlorophenyl)-2-oxo-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclohexanesulfonamide, N-(2-chlorophenyl)-2-oxo-

There total 3 articles about Cyclohexanesulfonamide, N-(2-chlorophenyl)-2-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

o-chloroaniline (95-51-2) + 2-oxocyclohexylsulfonyl chloride (1020842-00-5) → N-(2-chlorophenyl)-2-oxocyclohexylsulfonamide (925234-63-5)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1016/j.bmc.2008.02.048

Reference yield:

potassium 2-oxocyclohexylsulfonate + o-chloroaniline (95-51-2) → N-(2-chlorophenyl)-2-oxocyclohexylsulfonamide (925234-63-5)

Guidance literature:

potassium 2-oxocyclohexylsulfonate; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 4h;

o-chloroaniline; With triethylamine; In dichloromethane; for 2h;

DOI:10.1016/j.bmcl.2019.126859

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → N-(2-chlorophenyl)-2-oxocyclohexylsulfonamide (925234-63-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate; sulfur trioxide dioxane complex / 1,2-dichloro-ethane

2.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 4 h / 20 °C

2.2: 2 h

With oxalyl dichloride; sulfur trioxide dioxane complex; potassium carbonate; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2019.126859

upstream raw materials:

o-chloroaniline

2-oxocyclohexylsulfonyl chloride

cyclohexanone

Downstream raw materials:

C₁₂H₁₆ClNO₃S

Refernces

• 1、 Li, Xinghai,Yang, Xinling,Liang, Xiaomei,Kai, Zhenpeng,Yuan, Huizu,Yuan, Dekai,Zhang, Jianjun,Wang, Ruiqing,Ran, Fuxiang,Qi, Shuhua,Ling, Yun,Chen, Fuheng,Wang, Daoquan. "Synthesis and biological activities of 2-oxocycloalkylsulfonamides". . p. 4538 - 4544. Retrieved 2008/09/21.