4-methylsulfinylphenyloxooxazolidinylmethylacetamide

Base Information Edit

Chemical Name:4-methylsulfinylphenyloxooxazolidinylmethylacetamide
CAS No.:96800-41-8
Molecular Formula:C13H16 N2 O4 S
Molecular Weight:296.34
Hs Code.:
Mol file:96800-41-8.mol

Synonyms:Acetamide,N-[[3-[4-(methylsulfinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-, (5S)-; DuP 105

Suppliers and Price of 4-methylsulfinylphenyloxooxazolidinylmethylacetamide

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 4 raw suppliers

Chemical Property of 4-methylsulfinylphenyloxooxazolidinylmethylacetamide Edit

Chemical Property:

Vapor Pressure:3.38E-13mmHg at 25°C
Boiling Point:574.4°Cat760mmHg
Flash Point:301.2°C
PSA：94.92000
Density:1.4g/cm³
LogP:2.20690

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-methylsulfinylphenyloxooxazolidinylmethylacetamide

There total 8 articles about 4-methylsulfinylphenyloxooxazolidinylmethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 96800-15-6
(S)-N-({3-[4-(methylthio)phenyl]-2-oxo-5-oxazolidinyl}methyl)acetamide

: 96800-41-8
(S)-N-<<3-<4(S)-(methylsulfinyl)phenyl>-2-oxo-5-oxazolidinyl>methyl>acetamide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -30 ℃; for 0.5h;
DOI:10.1021/jm00128a003

Reference yield:

: 1632-84-4
4-(methylthio)phenyl isocyanate

: 96800-41-8
(S)-N-<<3-<4(S)-(methylsulfinyl)phenyl>-2-oxo-5-oxazolidinyl>methyl>acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: 100 percent / LiBr, n-Bu₃PO / xylene / 2 h / Heating

2: 100 percent / sodium methoxide / methanol / 2 h / Ambient temperature

3: 74 percent / pyridine / 15 °C

4: 93 percent / 18-crown-6, sodium azide / dimethylformamide / 5 h / 70 °C

5: 60 percent / Et₃N, propane-1,3-dithiol / 1) 40 deg C, 1 h, 2) 50 deg C, 1 h, 3) r.t., 18 h

6: 84 percent / NaOH / H₂O; tetrahydrofuran / 0 - 5 °C

7: 35 percent / 85percent m-chloroperbenzoic acid / CH₂Cl₂ / 0.5 h / -30 °C

With pyridine; 1.3-propanedithiol; sodium hydroxide; sodium azide; 18-crown-6 ether; Tributylphosphine oxide; sodium methylate; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium bromide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; xylene;
DOI:10.1021/jm00128a003

Reference yield:

: 96800-13-4
(R)-<3-<4-(methylthio)phenyl>-2-oxo-5-oxazolidinyl>methyl azide

: 96800-41-8
(S)-N-<<3-<4(S)-(methylsulfinyl)phenyl>-2-oxo-5-oxazolidinyl>methyl>acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / Et₃N, propane-1,3-dithiol / 1) 40 deg C, 1 h, 2) 50 deg C, 1 h, 3) r.t., 18 h

2: 84 percent / NaOH / H₂O; tetrahydrofuran / 0 - 5 °C

3: 35 percent / 85percent m-chloroperbenzoic acid / CH₂Cl₂ / 0.5 h / -30 °C

With 1.3-propanedithiol; sodium hydroxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jm00128a003